Pharmacokinetic interaction studies of tanshinones with tolbutamide, a model CYP2C11 probe substrate, using liver microsomes, primary hepatocytes and in vivo in the rat.

Pharmacokinetic interaction studies of tanshinones with tolbutamide, a model CYP2C11 probe substrate, using liver microsomes, primary hepatocytes and in vivo in the rat. post thumbnail image

The results of Danshen and its lively parts (tanshinone I, tanshinone IIA, dihydrotanshinone and cryptotanshinone) on tolbutamide 4-hydroxylation was investigated within the rat. Danshen (0.125-2mg/ml) decreased 4-hydroxy-tolbutamide formation in vitro and in vivo. Enzyme kinetics research confirmed that inhibition of tolbutamide 4-hydroxylase exercise was aggressive and concentration-dependent. The Ok(i) values of the tanshinones have been: dihydrotanshinone (8.92microM), cryptotanshinone (24.5microM), tanshinone I (80.3microM) and tanshinone IIA (242.9microM). In freshly ready main rat hepatocytes, tanshinones inhibited tolbutamide 4-hydroxylation in a concentration-dependent method, with EC(40) values within the order: cryptotanshinone (15.8microM), tanshinone IIA (16.2microM), dihydrotanshinone (20.1microM) and tanshinone I (48.2microM).

In entire animal research, single dose Danshen remedy (50 or 200mg/kg, i.p.) elevated tolbutamide clearance (17-26.9%), decreased AUC (14.4-20.9%) and elevated the Vd (7.26%). Three-day Danshen remedy (200mg/kg/day, i.p.) decreased the C(preliminary), elevated T(half of) and Vd however didn’t have an effect on tolbutamide clearance and AUC. Tolbutamide-4-hydroxylation in vivo was decreased by Danshen after acute and after 3-day remedy, with decreases within the AUC of 4-hydroxy-tolbutamide (15-28%) over the time interval studied. Regardless of aggressive inhibition of rat CYP2C11 in vitro and in vivo, as proven by the lower in tolbutamide 4-hydroxylation, solely minor modifications in tolbutamide pharmacokinetics was noticed.

Earlier research advised that lamotrigene (LTG) underwent bioactivation to a reactive aryl epoxide intermediate in rats. However, definitive constructions of those thioether conjugates, which are sometimes wanted to substantiate the mechanism of bioactivation and id of reactive intermediate(s), weren’t absolutely established. Within the current examine, GSH, cysteinylglycine, and N-acetyl cysteine conjugates of LTG have been remoted from bile of rats orally dosed with LTG (100 mg/kg), and their constructions have been absolutely elucidated by LC/MS and NMR.

The definitive structural characterization of those metabolites supplied proof for the existence of a reactive aryl epoxide that was trapped as a GSH adduct. In vitro research utilizing varied hepatic mobile and subcellular fractions obtained from human and rat have been carried out to reveal that LTG underwent bioactivation to type a GSH conjugate that was equivalent to the one initially characterised from in vivo research. This examine illustrated that the herb-drug interplay potential must be monitored by each in vitro and in vivo biotransformation/ pharmacokinetic parameters.

In vitro glucuronidation of two,2-bis(bromomethyl)-1,3-propanediol by microsomes and hepatocytes from rats and people.

2,2-Bis(bromomethyl)-1,3-propanediol (BMP) is a brominated flame retardant utilized in unsaturated polyester resins. In a 2-year bioassay BMP was proven to be a multisite carcinogen in rats and mice. As a result of glucuronidation is the important thing metabolic transformation of BMP by rats, on this examine the in vitro hepatic glucuronidation of BMP was in contrast throughout a number of species. As well as, the glucuronidation actions of human intestinal microsomes and particular human hepatic UDP-glucuronosyltransferase (UGT) enzymes for BMP have been decided. To discover different potential routes of metabolism for BMP, research have been performed with rat and human hepatocytes.

Incubation of hepatic microsomes with BMP within the presence of UDP-glucuronic acid resulted within the formation of a BMP monoglucuronide. The order of hepatic microsomal glucuronidation exercise of BMP was rats, mice>>) hamsters>> monkeys>>>> people. The speed of glucuronidation by rat hepatic microsomes was 90-fold larger than that of human hepatic microsomes. Human intestinal microsomes transformed BMP to BMP glucuronide at a charge even decrease than that of human hepatic microsomes. Among the many human UGT enzymes examined, solely UGT2B7 had detectable glucuronidation exercise for BMP.

Pharmacokinetic interaction studies of tanshinones with tolbutamide, a model CYP2C11 probe substrate, using liver microsomes, primary hepatocytes and in vivo in the rat.

BMP monoglucuronide was the one metabolite fashioned when BMP was incubated with suspensions of freshly remoted hepatocytes from male F-344 rats or with cryopreserved human hepatocytes. Glucuronidation of BMP in human hepatocytes was extraordinarily low. General, the outcomes assist in vivo research in rats by which BMP glucuronide was the one metabolite discovered. The poor glucuronidation capability of people for BMP means that the pharmacokinetic profile of BMP in people shall be dramatically completely different from that of rodents.

Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes.

The metabolism and lively transport of ritonavir and saquinavir have been studied utilizing sandwich-cultured rat hepatoyctes and rat liver microsomes. For ritonavir 4 comparable metabolites have been noticed within the sandwich-culture and in microsomes. For saquinavir eight metabolites have been noticed in sandwich-culture and 14 completely different metabolites in microsomes. Ketoconazole didn’t have an effect on the metabolism of ritonavir in sandwich-culture or microsomes and barely inhibited the metabolism of saquinavir in sandwich-culture. This inhibition resulted in a distinct metabolite profile for saquinavir in microsomes. Ritonavir had a pronounced inhibiting impact on the metabolism of saquinavir and affected the hydroxylation of 6beta-testosterone negatively.

Within the lively transport research, cyclosporin A and PSC833 enhanced the metabolism of ritonavir, suggesting that ritonavir is generally excreted into the bile canaliculi. Verapamil, confirmed no impact on the metabolism of ritonavir. The intrinsic clearance was estimated at 1.65 and 67.5 microl/min/1 x 10(6) cells and the hepatic metabolism clearance at 0.017 and 6.83ml/min/SRW for ritonavir and saquinavir respectively. In conclusion, for saquinavir the metabolism charge and the quantity of metabolites produced was greater than for ritonavir.

cDNA from Liver Cirrhosis: Liver

C1236149Lcs 40 reactions
EUR 668
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Liver Membrane Liver Cirrhosis Lysate

XBL-10671 0.1 mg
EUR 626.75
Description: Human liver tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human liver tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated liver tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated liver tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Liver X Receptor Alpha (LXRa) Polyclonal Antibody (Bovine), APC

4-PAC044Bo01-APC
  • EUR 389.00
  • EUR 3905.00
  • EUR 1070.00
  • EUR 503.00
  • EUR 238.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Liver X Receptor Alpha (LXRa). This antibody is labeled with APC.

Liver X Receptor Alpha (LXRa) Polyclonal Antibody (Bovine), Cy3

4-PAC044Bo01-Cy3
  • EUR 477.00
  • EUR 5165.00
  • EUR 1385.00
  • EUR 629.00
  • EUR 276.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Liver X Receptor Alpha (LXRa). This antibody is labeled with Cy3.

Liver X Receptor Alpha (LXRa) Polyclonal Antibody (Bovine), HRP

4-PAC044Bo01-HRP
  • EUR 354.00
  • EUR 3401.00
  • EUR 944.00
  • EUR 452.00
  • EUR 223.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Liver X Receptor Alpha (LXRa). This antibody is labeled with HRP.

Liver X Receptor Alpha (LXRa) Polyclonal Antibody (Bovine), PE

4-PAC044Bo01-PE
  • EUR 331.00
  • EUR 3144.00
  • EUR 876.00
  • EUR 422.00
  • EUR 210.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Liver X Receptor Alpha (LXRa). This antibody is labeled with PE.

Liver X Receptor Alpha (LXRa) Polyclonal Antibody (Bovine), Biotinylated

4-PAC044Bo01-Biotin
  • EUR 344.00
  • EUR 2922.00
  • EUR 843.00
  • EUR 427.00
  • EUR 233.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Liver X Receptor Alpha (LXRa). This antibody is labeled with Biotin.

Liver X Receptor Alpha (LXRa) Polyclonal Antibody (Bovine), FITC

4-PAC044Bo01-FITC
  • EUR 331.00
  • EUR 3144.00
  • EUR 876.00
  • EUR 422.00
  • EUR 210.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Liver X Receptor Alpha (LXRa). This antibody is labeled with FITC.

ELISA kit for Bovine Glycogen phosphorylase, liver form (PYGL)

KTE10142-48T 48T
EUR 354
Description: Quantitative sandwich ELISA for measuring Bovine Glycogen phosphorylase, liver form (PYGL) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Bovine Glycogen phosphorylase, liver form (PYGL)

KTE10142-5platesof96wells 5 plates of 96 wells
EUR 2252
Description: Quantitative sandwich ELISA for measuring Bovine Glycogen phosphorylase, liver form (PYGL) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Bovine Glycogen phosphorylase, liver form (PYGL)

KTE10142-96T 96T
EUR 572
Description: Quantitative sandwich ELISA for measuring Bovine Glycogen phosphorylase, liver form (PYGL) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Bovine FABP1/ Fatty acid-binding protein, liver ELISA Kit

E0092Bo 1 Kit
EUR 717

ELISA kit for Bovine Fatty acid-binding protein, liver

EK4389 96 tests
EUR 586
Description: Enzyme-linked immunosorbent assay kit for quantification of Bovine Fatty acid-binding protein, liver in samples from serum, plasma, tissue homogenates and other biological fluids.

Bovine Liver- expressed antimicrobial peptide 2, LEAP2 ELISA KIT

ELI-20184b 96 Tests
EUR 928

Bovine Fatty acid- binding protein, liver, FABP1 ELISA KIT

ELI-07065b 96 Tests
EUR 928

LEAP2 ELISA Kit| Bovine Liver-expressed antimicrobial peptide 2

EF011562 96 Tests
EUR 689

50ml TC Tubes, Conical, 440 units/box

04-5540150 440 units/box
EUR 71

GMP IL4, 50µg

04-GMP-HU-IL4-50UG 50µg
EUR 483
Description: Recombinant Human IL-4 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 15000 Dalton. The rHuIL-4 is purified by proprietary chromatographic techniques.

SDS-Blue™ - Coomassie based solution for protein staining in SDS-PAGE

04-GSB
  • EUR 120.00
  • EUR 80.00
  • 1L
  • 500mL
Description: SDS-Blue™ is an innovative patented formula, based on Coomassie blue, that comes in a convenient ready to use format for staining proteins in SDS-PAGE (sodium dodecyl sulphate–polyacrylamide gel electrophoresis). The formulation of SDS-Blue™ provides numerous advantages compared to the classic Coomassie staining or to other similar protein stains. SDS-Blue™ provides higher sensitivity, virtually no background and eliminates the need for destaining of the gel due to its high specificity and affinity to bind to protein only. Not only does SDS-Blue™ yield clear and sharp bands, but it also contains no methanol and acetic acid, making it non-hazardous, safe to handle and friendly to the environment when disposed of. Two other advantages that make SDS-Blue™ the better option is that it is not light sensitive and can be stored at ambient temperature for 24 months. And this provides a considerable convenience, especially to laboratories that need and keep big amount of protein staining solutions – no more jammed refrigerators, you can keep SDS-Blue™ wherever it is most convenient for You!

rHu IL 2 , 3MIU

04-RHIL2-02F01 1 vial
EUR 249
Description: Recombinant human interleukin-2 is a sterile protein product for injection. rHuIL-2 is produced by recombinant DNA technology using Yeast. It is a highly purified protein containing 133 amino acids, with cysteine mutated to alanine at 125 amino acid position, and has a molecular weight of approximately 15.4kD, non-glycosylated.

rHu IL 2 , 3MIU , Lot 200908F02

04-RHIL2-08F02 1 vial
EUR 249
Description: Recombinant human interleukin-2 is a sterile protein product for injection. rHuIL-2 is produced by recombinant DNA technology using Yeast. It is a highly purified protein containing 133 amino acids, with cysteine mutated to alanine at 125 amino acid position, and has a molecular weight of approximately 15.4kD, non-glycosylated.

PRE-GMP rHu GM-CSF, Molgramostim-Leukoma

04-RHUGM-CSF-7A10 300 µg
EUR 385
Description: Recombinant human GM-CSF produced in E.coli is a single, non-glycosylated, polypeptide chain containing 127 amino acids, two pairs of disulfide bonds and having a molecular mass of approximately 14.5kD.

Total Protein from Liver Cirrhosis: Liver

P1236149Lcs 1 mg
EUR 461
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein from Liver Cirrhosis: Liver

P3236149Lcs 0.1 mg
EUR 408
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA from Liver Cirrhosis: Liver

R1236149Lcs-50 50 ug
EUR 351
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Paraffin Tissue Section - Liver Cirrhosis: Liver

T2236149Lcs 5 slides
EUR 257
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Liver Lysate

1304 0.1 mg
EUR 191
Description: Liver tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Liver Lysate

1404 0.1 mg
EUR 191
Description: Liver tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Liver Lysate

1464 0.1 mg
EUR 191
Description: Liver tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Liver Lysate

21-105 0.1 mg
EUR 285.5
Description: Bovine liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The bovine liver tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Liver Lysate

21-302 0.1 mg
EUR 285.5
Description: Monkey (Rhesus) liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The monkey (Rhesus) liver tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Liver Lysate

21-406 0.1 mg
EUR 285.5
Description: Porcine liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The porcine liver tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Liver Lysate

21-419 0.1 mg
EUR 285.5
Description: Rabbit liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The rabbit liver tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Liver X Receptor Alpha (LXRa) Polyclonal Antibody (Bovine), APC-Cy7

4-PAC044Bo01-APC-Cy7
  • EUR 659.00
  • EUR 7690.00
  • EUR 2020.00
  • EUR 886.00
  • EUR 356.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Liver X Receptor Alpha (LXRa). This antibody is labeled with APC-Cy7.

Fatty Acid Binding Protein 1, Liver (FABP1) Polyclonal Antibody (Bovine)

4-PAB566Bo01
  • EUR 267.00
  • EUR 2826.00
  • EUR 697.00
  • EUR 338.00
  • EUR 222.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Fatty Acid Binding Protein 1, Liver (FABP1)

Bovine L-FABP(Liver Fatty acid Binding Protein) ELISA Kit

EB0095 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Cattle;Sensitivity: 0.469 ng/ml

Fatty Acid Binding Protein 1, Liver (FABP1) Polyclonal Antibody (Bovine), APC

4-PAB566Bo01-APC
  • EUR 376.00
  • EUR 3707.00
  • EUR 1020.00
  • EUR 483.00
  • EUR 232.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Fatty Acid Binding Protein 1, Liver (FABP1). This antibody is labeled with APC.

Fatty Acid Binding Protein 1, Liver (FABP1) Polyclonal Antibody (Bovine), Biotinylated

4-PAB566Bo01-Biotin
  • EUR 334.00
  • EUR 2776.00
  • EUR 806.00
  • EUR 412.00
  • EUR 228.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Fatty Acid Binding Protein 1, Liver (FABP1). This antibody is labeled with Biotin.

Fatty Acid Binding Protein 1, Liver (FABP1) Polyclonal Antibody (Bovine), Cy3

4-PAB566Bo01-Cy3
  • EUR 459.00
  • EUR 4901.00
  • EUR 1319.00
  • EUR 602.00
  • EUR 267.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Fatty Acid Binding Protein 1, Liver (FABP1). This antibody is labeled with Cy3.

Fatty Acid Binding Protein 1, Liver (FABP1) Polyclonal Antibody (Bovine), FITC

4-PAB566Bo01-FITC
  • EUR 320.00
  • EUR 2985.00
  • EUR 836.00
  • EUR 406.00
  • EUR 205.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Fatty Acid Binding Protein 1, Liver (FABP1). This antibody is labeled with FITC.

Fatty Acid Binding Protein 1, Liver (FABP1) Polyclonal Antibody (Bovine), HRP

4-PAB566Bo01-HRP
  • EUR 342.00
  • EUR 3229.00
  • EUR 901.00
  • EUR 435.00
  • EUR 217.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Fatty Acid Binding Protein 1, Liver (FABP1). This antibody is labeled with HRP.

Fatty Acid Binding Protein 1, Liver (FABP1) Polyclonal Antibody (Bovine), PE

4-PAB566Bo01-PE
  • EUR 320.00
  • EUR 2985.00
  • EUR 836.00
  • EUR 406.00
  • EUR 205.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Fatty Acid Binding Protein 1, Liver (FABP1). This antibody is labeled with PE.

L-FABP ELISA Kit| Bovine Liver Fatty acid Binding Protein ELISA

EF011047 96 Tests
EUR 689

Liver Cancer Exosome

P141-LV - Ask for price

Liver Arginase Antibody

49867-100ul 100ul
EUR 333

Liver Arginase Antibody

49867-50ul 50ul
EUR 239

Chang Liver (HeLa)

C0050007 One Frozen vial
EUR 543

CK LIVER 1kg*

43023-2 1 kg
EUR 240.09

Human Liver Ferritin

7-05176 200µg Ask for price

Human Liver Ferritin

7-05177 1mg Ask for price

Human Liver Ferritin

7-05178 10mg Ask for price

Liver Ferritin Protein

20-abx260074
  • EUR 2903.00
  • EUR 648.00
  • EUR 286.00
  • 10 mg
  • 1 mg
  • 200 ug

liver Arginase Antibody

abx234800-100ug 100 ug
EUR 481

liver Arginase Antibody

abx234801-100ug 100 ug
EUR 481

anti-liver Arginase

YF-PA10306 50 ug
EUR 363
Description: Mouse polyclonal to liver Arginase

anti-liver Arginase

YF-PA10307 50 ug
EUR 363
Description: Mouse polyclonal to liver Arginase

anti-liver Arginase

YF-PA10308 100 ul
EUR 403
Description: Rabbit polyclonal to liver Arginase

anti-liver Arginase

YF-PA10309 100 ug
EUR 403
Description: Rabbit polyclonal to liver Arginase

anti-liver FABP

YF-PA11679 50 ul
EUR 363
Description: Mouse polyclonal to liver FABP

anti-liver FABP

YF-PA11680 100 ug
EUR 403
Description: Rabbit polyclonal to liver FABP

anti-liver FABP

YF-PA11681 100 ug
EUR 403
Description: Rabbit polyclonal to liver FABP

anti-liver FABP

YF-PA23687 50 ul
EUR 334
Description: Mouse polyclonal to liver FABP

Ferritin, Human liver

P1449-100
EUR 164

Ferritin protein (Liver)

30-AF10 1 mg
EUR 308
Description: Highly purfied Ferritin protein isolated from human liver

Liver Tumor Lysate

1330 0.1 mg
EUR 254
Description: Liver tumor tissue lysate was prepared by homogenization in lysis buffer (10 mM HEPES pH7.9, 1.5 mM MgCl2, 10 mM KCl, 1 mM ethylenediaminetetraacetic acid, 10% glycerol, 1% NP-40, and a cocktail of protease inhibitors). Tissue and cell debris was removed by centrifugation. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Liver Lupus Lysate

XBL-10359 0.1 mg
EUR 663.5
Description: Human liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human liver tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Fetal Liver Lysate

XBL-10409 0.1 mg
EUR 285.5
Description: Fetal human liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The fetal human liver tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Liver Cytoplasmic Lysate

XBL-10666 0.1 mg
EUR 227.75
Description: Human liver tissue cytoplasmic protein lysate was prepared by isolating the cytoplasmic protein from whole tissue homogenates using a proprietary technique. The human liver tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The cytoplasmic protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, glycerol, and a cocktail of protease inhibitors. For quality control purposes, the isolated liver tissue cytoplasmic protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated liver tissue cytoplasmic protein is then Western analyzed by GAPDH antibody, and the expression level is consistent with each lot.

Liver Membrane Lysate

XBL-10667 0.1 mg
EUR 516.5
Description: Human liver tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human liver tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated liver tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated liver tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

Fatty Acid Binding Protein 1, Liver (FABP1) Polyclonal Antibody (Bovine), APC-Cy7

4-PAB566Bo01-APC-Cy7
  • EUR 632.00
  • EUR 7294.00
  • EUR 1921.00
  • EUR 846.00
  • EUR 344.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Bovine Fatty Acid Binding Protein 1, Liver (FABP1). This antibody is labeled with APC-Cy7.

Genomic DNA from Liver Cirrhosis: Liver, from a single donor

D1236149Lcs 50 ug
EUR 446
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Recombinant Phosphofructokinase, Liver (PFKL)

4-RPD406Hu01
  • EUR 465.57
  • EUR 227.00
  • EUR 1470.88
  • EUR 556.96
  • EUR 1013.92
  • EUR 374.00
  • EUR 3527.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Phosphofructokinase, Liver expressed in: E.coli

Recombinant Phosphofructokinase, Liver (PFKL)

4-RPD406Ra01
  • EUR 501.41
  • EUR 237.00
  • EUR 1605.28
  • EUR 601.76
  • EUR 1103.52
  • EUR 398.00
  • EUR 3863.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Phosphofructokinase, Liver expressed in: E.coli

Rat Liver Tissue Lysate

LYSATE0003 200ug
EUR 150
Description: This cell lysate is prepared from rat liver tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.

Mouse Liver Tissue Lysate

LYSATE0013 200ug
EUR 150
Description: This cell lysate is prepared from mouse liver tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.

Human Ferritin (Liver) Antibody

11321-05011 150 ug
EUR 217

Rat Ferritin (Liver) Antibody

11901-05011 150 ug
EUR 217

Mouse Ferritin (Liver) Antibody

11911-05011 150 ug
EUR 217

Anti-Liver Antigen antibody

STJ16101073 100 µg
EUR 354

Anti-Liver Antigen antibody

STJ16101074 100 µg
EUR 354

Mouse Liver Nuclear Extract

X12014 500 µg Ask for price
Description: kits suitable for this type of research

Liver Cancer Exosome RNA

P241-LV - Ask for price

Phosphofructokinase, Liver (PFKL) Antibody

20-abx130089
  • EUR 453.00
  • EUR 133.00
  • EUR 1302.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Phosphofructokinase, Liver (PFKL) Antibody

20-abx114459
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Phosphorylase, Glycogen, Liver Antibody

20-abx114508
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Mouse Liver PrimaCell: Hepatocytes

2-82100 1 Kit Ask for price

Rat Liver PrimaCell: Hepatocytes

2-82595 1 Kit Ask for price

Human Liver PrimaCell: Hepatocytes

2-96121 1 Kit Ask for price

Liver Canuliculi(HSA98) Antibody

BNC040098-100 100uL
EUR 199
Description: Primary antibody against Liver Canuliculi(HSA98), CF405S conjugate, Concentration: 0.1mg/mL

Liver Canuliculi(HSA98) Antibody

BNC040098-500 500uL
EUR 544
Description: Primary antibody against Liver Canuliculi(HSA98), CF405S conjugate, Concentration: 0.1mg/mL

Phosphofructokinase, Liver (PFKL) Antibody

20-abx317882
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Liver Ferritin Protein

abx060939-1mg 1 mg
EUR 453

Ritonavir had a powerful inhibitory impact on the metabolism of saquinavir and gave the impression to be excreted into the bile. The precise mechanism liable for GSH depletion is unknown at current. Additional experiments are wanted to completely perceive the consequences of BNZs on the parasite GSH analogue, trypanothione, which can be a direct or oblique goal for these brokers. Pharmacokinetic analysis of those compounds is required to additional progress their improvement as potential new remedies for leishmaniasis.

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