In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.

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In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans. post thumbnail image

The in vitro metabolism of rivaroxaban, a novel, oral, direct issue Xa inhibitor for the prevention and remedy of thromboembolic issues, was investigated in a number of species, together with people. The target of this research was to elucidate metabolite constructions and establish the metabolic pathways to offer assist for in vivo security and medical research. [(14)C]Rivaroxaban was incubated with liver microsomes and hepatocytes of rats, canine, and people. The samples had been analyzed by high-performance liquid chromatography-(14)C-tandem mass spectroscopy, to generate metabolite profiles and suggest or affirm the constructions of the metabolites shaped. In vitro metabolite profiles confirmed no main variations between species.

The principle oxidative metabolic pathways recognized for all species had been hydroxylation on the morpholinone moiety (M-2, M-3, and M-8) and to a lesser extent on the oxazolidinone moiety (M-9). M-2 was the primary metabolite in all microsomal incubations. M-1, a morpholinone ring-opened product shaped by additional oxidation of M-2, was the primary metabolite in all hepatocyte incubations. Different pathways had been amide hydrolysis on the morpholinone ring (M-7) and the chlorothiophene amide moiety (M-13 and M-15). In hepatocytes, M-13 was readily conjugated with glycine, resulting in M-4. The metabolic destiny of unlabeled M-15 was investigated individually.

Incubations with human liver microsomes and hepatocytes confirmed that M-15 was first oxidized to the aldehyde intermediate M-16 and subsequently diminished to M-17 (alcohol) or oxidized to M-18 (carboxylic acid). No metabolism on the chlorothiophene moiety itself was discovered. Total, rivaroxaban confirmed no species variations in metabolism, with completely different unbiased metabolic pathways and no formation of reactive metabolites.

In vivo clearance predictions from in vitro assays require scaling elements to narrate the concentrations of hepatocytes or microsomal protein to the intact liver. 2. The goals had been to measure the variability in scaling elements for Wistar rat and beagle canine for which the literature is especially scarce and decide any intercourse variations. 3. Scaling elements had been decided by evaluating the cytochrome P450 (P450) content material in hepatocytes or microsomes in opposition to the P450 content material of recent liver homogenate. Using recent homogenate is really helpful as freezing can improve contamination and have an effect on the P450 assay.

Comparability of genistein metabolism in rats and people utilizing liver microsomes and hepatocytes.

Species variations and metabolism are probably the most essential elements in contemplating the results of genistein. The goal of this research was to have a greater information of the metabolic destiny of genistein in people as in contrast with rats. For this goal, radiolabeled genistein was incubated with human and rat liver microsomes and with cryopreserved hepatocytes from each species. Incubations had been carried out utilizing a variety of genistein concentrations to research the kinetics of formation of the metabolites. Metabolite profiling was obtained utilizing an HPLC system linked to a radioactivity detector.

In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.

Identification of the metabolites was primarily based on their retention occasions as in contrast with these of genuine requirements and on LC-MS (ESI-MS/MS) or NMR analyses. In each species, liver microsomes produced the identical three hydroxylated metabolites (8-OH, 6-OH and three’-OH-genistein) whereas cryopreserved hepatocytes produced the identical glucurono- and sulfo-conjugates (genistein 4′-O-sulfate 7-O-glucuronide, genistein 7-O-glucuronide, genistein 4′-O-glucuronide, genistein 7-O-sulfate and genistein 4′-O-sulfate). The speed of metabolism assorted with species. 3′-Hydroxygenistein was the predominant metabolite produced by rat liver microsomes, whereas in people 3′-hydroxy and 8-hydroxygenistein had been produced in the identical vary.

Metabolism of prazosin in rat, canine, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry.

Prazosin (2-[4-(2-furanoyl)-piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline) is an antihypertensive agent that was launched to the market in 1976. It has since established a wonderful security document. Nonetheless, in vitro metabolism of prazosin has not been investigated. This research describes the in vitro biotransformation of prazosin in liver microsomes from rats, canine, and people, in addition to rat and human cryopreserved hepatocytes and characterization of metabolites utilizing liquid chromatography/tandem mass spectrometry. The main in vivo biotransformation pathways reported beforehand in rats and canine embody demethylation, amide hydrolysis, and O-glucuronidation.

These metabolic pathways had been additionally confirmed in our research. As well as, a number of new metabolites had been characterised, together with a secure carbinolamine, an iminium species, and an enamine-all shaped by way of oxidation of the piperazine ring. Two ring-opened metabolites generated following oxidative cleavage of the furan ring had been additionally recognized. Utilizing semicarbazide hydrochloride as a trapping agent, an intermediate arising from opening of the furan ring was captured as a pyridazine product. Within the presence of glutathione, three glutathione conjugates had been detected in microsomal incubations, though they weren’t detected in cryopreserved hepatocytes.

Lactoferrin (Seminal Plasma) Protein
20-abx262658
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Mouse Secreted seminal- vesicle Ly- 6 protein 1, Sslp1 ELISA KIT
ELI-41041m 96 Tests
EUR 1038

Bovine Secreted seminal- vesicle Ly- 6 protein 1, SSLP1 ELISA KI
ELI-18704b 96 Tests
EUR 1113.6

Porcine Secreted seminal- vesicle Ly- 6 protein 1, SSLP1 ELISA K
ELI-41771p 96 Tests
EUR 1113.6

Seminal Plasma Inhibin (67-94) (human)
H-1602.0500 0.5mg
EUR 400.8
Description: Sum Formula: C150H240N36O43S2; CAS# [96182-95-5]

Seminal Plasma Inhibin (67-94) (human)
H-1602.1000 1.0mg
EUR 691.2
Description: Sum Formula: C150H240N36O43S2; CAS# [96182-95-5]

Bovine Seminal ribonuclease, SRN ELISA KIT
ELI-40880b 96 Tests
EUR 1113.6

Rat seminal plasma protein homolog 1 ELISA kit
E02B0856-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat seminal plasma protein homolog 1 ELISA kit
E02B0856-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat seminal plasma protein homolog 1 ELISA kit
E02B0856-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog seminal plasma protein homolog 1 ELISA kit
E08B0856-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog seminal plasma protein homolog 1 ELISA kit
E08B0856-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog seminal plasma protein homolog 1 ELISA kit
E08B0856-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig seminal plasma protein homolog 1 ELISA kit
E07B0856-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig seminal plasma protein homolog 1 ELISA kit
E07B0856-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig seminal plasma protein homolog 1 ELISA kit
E07B0856-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat seminal plasma protein homolog 1 ELISA kit
E06B0856-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat seminal plasma protein homolog 1 ELISA kit
E06B0856-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat seminal plasma protein homolog 1 ELISA kit
E06B0856-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human seminal plasma protein homolog 1 ELISA kit
E01B0856-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human seminal plasma protein homolog 1 ELISA kit
E01B0856-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human seminal plasma protein homolog 1 ELISA kit
E01B0856-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse seminal plasma protein homolog 1 ELISA kit
E03B0856-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse seminal plasma protein homolog 1 ELISA kit
E03B0856-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse seminal plasma protein homolog 1 ELISA kit
E03B0856-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

LTF S.Plasma Lactoferrin Human (Seminal Plasma) protein
PROTP02788-2 Regular: 10ug
EUR 380.4
Description: The Human Lactoferrin produced from pooled Human seminal plasma has a molecular mass of 76.165kDa (calculated without glycosylation) containing 691 amino acid residues.

Rabbit seminal plasma protein homolog 1 ELISA kit
E04B0856-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit seminal plasma protein homolog 1 ELISA kit
E04B0856-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit seminal plasma protein homolog 1 ELISA kit
E04B0856-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey seminal plasma protein homolog 1 ELISA kit
E09B0856-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey seminal plasma protein homolog 1 ELISA kit
E09B0856-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey seminal plasma protein homolog 1 ELISA kit
E09B0856-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat seminal plasma protein homolog 1(BSPH1) ELISA kit
E02S0303-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat seminal plasma protein homolog 1(BSPH1) ELISA kit
E02S0303-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat seminal plasma protein homolog 1(BSPH1) ELISA kit
E02S0303-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig seminal plasma protein homolog 1(BSPH1) ELISA kit
E07S0303-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig seminal plasma protein homolog 1(BSPH1) ELISA kit
E07S0303-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig seminal plasma protein homolog 1(BSPH1) ELISA kit
E07S0303-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog seminal plasma protein homolog 1(BSPH1) ELISA kit
E08S0303-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog seminal plasma protein homolog 1(BSPH1) ELISA kit
E08S0303-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog seminal plasma protein homolog 1(BSPH1) ELISA kit
E08S0303-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig seminal plasma protein homolog 1 ELISA kit
E05B0856-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig seminal plasma protein homolog 1 ELISA kit
E05B0856-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig seminal plasma protein homolog 1 ELISA kit
E05B0856-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig seminal plasma protein homolog 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat seminal plasma protein homolog 1(BSPH1) ELISA kit
E06S0303-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat seminal plasma protein homolog 1(BSPH1) ELISA kit
E06S0303-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat seminal plasma protein homolog 1(BSPH1) ELISA kit
E06S0303-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse seminal plasma protein homolog 1(BSPH1) ELISA kit
E03S0303-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse seminal plasma protein homolog 1(BSPH1) ELISA kit
E03S0303-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse seminal plasma protein homolog 1(BSPH1) ELISA kit
E03S0303-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human seminal plasma protein homolog 1(BSPH1) ELISA kit
E01S0303-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human seminal plasma protein homolog 1(BSPH1) ELISA kit
E01S0303-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human seminal plasma protein homolog 1(BSPH1) ELISA kit
E01S0303-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit seminal plasma protein homolog 1(BSPH1) ELISA kit
E04S0303-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit seminal plasma protein homolog 1(BSPH1) ELISA kit
E04S0303-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit seminal plasma protein homolog 1(BSPH1) ELISA kit
E04S0303-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey seminal plasma protein homolog 1(BSPH1) ELISA kit
E09S0303-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey seminal plasma protein homolog 1(BSPH1) ELISA kit
E09S0303-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey seminal plasma protein homolog 1(BSPH1) ELISA kit
E09S0303-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig seminal plasma protein homolog 1(BSPH1) ELISA kit
E05S0303-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig seminal plasma protein homolog 1(BSPH1) ELISA kit
E05S0303-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig seminal plasma protein homolog 1(BSPH1) ELISA kit
E05S0303-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig seminal plasma protein homolog 1(BSPH1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Porcine Seminal plasma sperm motility inhibitor, SPMI ELISA KIT
ELI-41439p 96 Tests
EUR 1113.6

Mouse Bovine seminal plasma protein homolog 1, Bsph1 ELISA KIT
ELI-50141m 96 Tests
EUR 1038

Human Bovine seminal plasma protein homolog 1, BSPH1 ELISA KIT
ELI-33283h 96 Tests
EUR 988.8

Seminalplasmin Fragment (SPF) Analog
H-1636.0001 1.0mg
EUR 283.2
Description: Sum Formula: C76H123N17O16; CAS# [147958-06-3]

Seminalplasmin Fragment (SPF) Analog
H-1636.0005 5.0mg
EUR 1023.6
Description: Sum Formula: C76H123N17O16; CAS# [147958-06-3]

Rabbit Anti-Human PiT2 (GLVR2/Ram-1) antiserum # 1
PIT21-S 100 ul
EUR 548.4

Human PiT2 (GLVR2/Ram-1) Control/blocking peptide #1
PIT21-P 100 ug
EUR 196.8

Rabbit Anti-Human PiT2 (GLVR2/Ram-1) IgG #1, aff pure
PIT21-A 100 ug
EUR 578.4

Shikari (Q-RAM) Ramucirumab (Cyramza)Free drug ELISA kit
RAM-FD-CYR 1x96-wells test plate
EUR 1053.6
Description: Enzyme Immunoassay for detection of freeRamucirumab (Cyramza) in human serum and plasma samples.

Purified Ram Cyclooxygenase (Cox-1) Western blot +ve control
COX11-C 100 ul
EUR 343.2

Purified Ram Cyclooxygenase (Cox-2) Western blot +ve control
COX21-C 100 ul
EUR 343.2

Testis seminoma and lymphoma tissue array
TE802 each
EUR 270
Description: Testis seminoma and lymphoma tissue array, 80 cases/80 cores

Paraffin Tissue Section - Human Testis Tumor: Seminoma
T2235260-3 5 slides
EUR 238

Reproductive Tissue Dissociation System 2 (Seminiferous tubules), Mouse and Rat
4-20412 ea Ask for price

Rabbit Anti-Ram Cyclooxygenase (Cox-1) IgG #1
COX11-A 100 ul
EUR 578.4

Reproductive Tissue Dissociation System 1 (Epithelial,Leydig, Luteal, ovaries, Sertolli, seminiforous tubules), Mouse and Rat
4-20411 ea Ask for price

Biovac 106 with 4L PP Vessel
PUM0500 EACH
EUR 2348.4

Ohaus Vessel Clamp
STI7278 EACH
EUR 243.6

Blood vessel disease spectrum (blood vessel cancer progression) tissue array
SO8010 each
EUR 306
Description: Blood vessel disease spectrum (blood vessel cancer progression) tissue array, 80 cases/80 cores

Foam Dewar - Mini Vessel - 130 ml
M-FD-130 130 ML
EUR 50
Description: Foam Dewar - Mini Vessel - 130 ml

HYPERSTACK VESSEL - 36
10036 1/pk
EUR 3672
Description: Stackable Cell Culture; High Yield Perf Cell Culture Chambers

HYPERSTACK VESSEL - 12
10012 1/pk
EUR 3470.4
Description: Stackable Cell Culture; High Yield Perf Cell Culture Chambers

Spare 4L vessel with Hoses
PUM0510 EACH
EUR 487.2

Locator JR PLUS Cryo Vessel
CRY1014 EACH
EUR 7033.2

Locator 4 PLUS Cryo Vessel
CRY1016 EACH
EUR 8295.6

Locator 6 PLUS Cryo Vessel
CRY1018 EACH
EUR 9195.6

Biovac 106 with 2L Glass Vessel
PUM0502 EACH
EUR 2200.8

Culture Vessel Fv 1Ltr 1000ml
QFV1L EACH
EUR 129.6

Culture Vessel Fv 2Ltr 2000ml
QFV2L EACH
EUR 205.2

Techne 1L Culture Vessel
TIS4120 EACH
EUR 812.4

HYPERSTACK VESSEL - 36 LAYER,NT,S,1/2
10037 1/pk
EUR 3566.4
Description: Stackable Cell Culture; High Yield Perf Cell Culture Chambers

HYPERSTACK VESSEL - 12 LAYER, NT,S,1/4
10013 1/pk
EUR 3631.2
Description: Stackable Cell Culture; High Yield Perf Cell Culture Chambers

Blood Vessel: Artery Lysate
21-270 0.1 mg
EUR 468.6
Description: Monkey (Rhesus) blood vessel artery tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The monkey (Rhesus) blood vessel artery tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the blood vessel artery tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The blood vessel artery tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Techne 125ml Culture Vessel
TIS4090 EACH
EUR 508.8

Techne 250ml Culture Vessel
TIS4100 EACH
EUR 508.8

Flat bottom vessel platform
MIX1366 EACH
EUR 24

Titration vessel for HI-904 (glass)
TIT1052 EACH
EUR 554.4

6-well reagent vessel for IsoPure Mini, cs 100
AP1016-6W 1 each
EUR 126

Titration vessel for HI-904 (assembly)
TIT1050 EACH
EUR 1003.2

Total Protein - Lupus: Blood Vessel: Artery
P1236013Lup 1 mg
EUR 471

Techne Biological Stirrer 4 x 500mL Vessel
TIS4020 EACH
EUR 2748

cDNA - Human Adult Normal Tissue: Blood Vessel: Vein
C1234020-10 10 reactions
EUR 215

SINGLE-USE QUENCH BAG FOR HYPERSTACK® VESSEL, 5L
91-200-76 1/pk
EUR 223.2
Description: Flexible Containers; Bioprocess Bags and Parts

SINGLE-USE MEDIA BAG FOR HYPERSTACK® VESSEL, 20L
91-200-77 1/pk
EUR 206.4
Description: Flexible Containers; Bioprocess Bags and Parts

SINGLE-USE TRYPSIN BAG FOR HYPERSTACK® VESSEL, 5L
91-200-75 1/pk
EUR 218.4
Description: Flexible Containers; Bioprocess Bags and Parts

Sterile plant culture vessel 700 mL transparent PS
DD017003 EACH
EUR 542.4

cDNA - Monkey (Rhesus) Normal Tissue: Blood Vessel: Vein
C1534020 40 reactions
EUR 578

cDNA - Human Adult Normal Tissue: Blood Vessel: Artery
C1234013-10 10 reactions
EUR 215

Total RNA - Human Adult Normal Tissue: Blood Vessel: Vein
R1234020-10 10 ug
EUR 191

These information assist ring opening of the furan by way of a reactive gamma-keto-alpha,beta-unsaturated aldehyde intermediate. Within the presence of UDP-glucuronic acid, prazosin underwent conjugation to type an N-glucuronide not reported beforehand. Our in vitro investigations have revealed further metabolic transformations of prazosin and have proven the potential of prazosin to endure bioactivation by means of metabolism of the furan ring to a reactive intermediate.

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