Asociación Española de Toxicología (AETOX) ISSN: 1697-0748

S9 fraction rat hepatocyte microsomes, slices, p450, beagle

In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.

The in vitro metabolism of rivaroxaban, a novel, oral, direct issue Xa inhibitor for the prevention and remedy of thromboembolic issues, was investigated in a number of species, together with people. The target of this research was to elucidate metabolite constructions and establish the metabolic pathways to offer assist for in vivo security and medical research. Rivaroxaban was incubated with liver microsomes and hepatocytes of rats, canine,...