Within the current examine, the in vitro metabolic habits of a benzopyridooxathiazepine (BZN), a potent tubulin polymerization inhibitor, was investigated by liquid chromatography-UV detection (LC-UV). First, easy and quick LC-UV strategies have been optimized and validated to judge the pharmacokinetic profile of BZN utilizing rat liver microsomes or hepatocytes main cultures suspensions. Regardless of the medium investigated, baseline decision between the interior commonplace and BZN was achieved in a run time lower than 15min utilizing a Symmetry ODS column (150mm×4.6mm i.d., 5μm) and a cell part consisting of acetonitrile/water/formic acid 60:40:0.1 (v/v/v). Linearity was assessed within the 0.1-50μM and within the 0.05-5μM focus ranges, respectively, in microsomal and hepatocyte matrix.
Based on the novel technique based mostly on the construct of the accuracy profile, whole error of the developed strategies was included inside the ±10% limits of acceptance. Then, from incubation of BZN with each liver microsomes and or hepatocytes, structural informations on part I and part II metabolites have been acquired utilizing liquid chromatography coupled to electrospray orbitrap mass spectrometer (LC-MS). Mass spectrum, double bond equal and elemental composition have been helpful knowledge to entry to the chemical construction of every metabolite.
In microsomal suspension, 4 predominant metabolites have been noticed together with monohydroxylation and dihydroxylation of the benzopyridooxathiazepine core, demethylation of the methoxyphenyl moiety, in addition to their mixtures. The part II metabolites detected in hepatocytes suspension have been the glucuronide adducts of each demethylated BZN and mono-oxygenated BZN. Primarily based on the structural elucidation of the metabolites detected, we proposed an in vitro metabolic pathway of BZN, a brand new tubulin polymerization inhibitor.
In vitro metabolism of BIIB021, an inhibitor of warmth shock protein 90, in liver microsomes and hepatocytes of rats, canines, and people and recombinant human cytochrome P450 isoforms.
Inhibition of warmth shock protein 90 (HSP90) ends in the degradation of oncoproteins that drive malignant development and induce cell loss of life, thus making HSP90 a possible goal of most cancers remedy. 6-Chloro-9-(4-methoxy-3, 5-dimethyl-pyridin-2-ylmethyl)-9H-purin-2-ylamine (BIIB021), an artificial HSP90 inhibitor, exhibited promising antitumor exercise in preclinical fashions. It’s at present in part II medical trials for the oral remedy of breast most cancers. The target of this examine was to acquire each quantitative and qualitative metabolic profiles of [(14)C]BIIB021 in rat, canine, and human liver microsomes and hepatocytes to supply assist for in vivo security and medical research.
The metabolites of [(14)C]BIIB021 have been recognized utilizing liquid chromatography-tandem mass spectrometry coupled with radiometric detection. BIIB021 was extensively metabolized in each liver microsomes and hepatocytes. The foremost oxidative metabolic pathways recognized for all species have been attributable to hydroxylation (M7) and O-demethylation (M2) of the methoxy-dimethylpyridine moiety. The vast majority of M7 in canine hepatocytes was additional conjugated to type the glucuronide (M4). Oxidative dechlorination (M6), monooxygenation (M10), and oxidative N-dealkylation of the methoxy-dimethylpyridine moiety (M11 and M12) have been noticed because the minor metabolic pathways in hepatocytes of all three species. A glutathione conjugate (M18) was additionally recognized in all species.
Its formation was catalyzed, partially, by soluble glutathione transferase by way of direct displacement of the chlorine on the amino-chloropurine moiety. Subsequent minor secondary metabolites M13, M14, M15, and M17 have been noticed in human, canine, and rat hepatocytes. Outcomes from incubations of BIIB021 with human recombinant cytochrome P450 (P450) isoforms and a P450 antibody inhibition examine in human liver microsomes urged that the formation of M7 is especially catalyzed by CYP2C19 and CYP3A4, whereas the formation of minor metabolite M2 in human liver microsomes most likely may very well be attributed to CYP3A4.
In vitro metabolism of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rat, monkey, and human liver microsomes and freshly remoted hepatocytes.
The in vitro metabolism of rivoglitazone, (RS)-5-{4-[(6-methoxy-1-methyl-1H-benzimidazol-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione monohydrochloride, a novel thiazolidinedione (TZD) peroxisome proliferator-activated receptor γ selective agonist, was studied in liver microsomes and freshly remoted hepatocytes of rat, monkey, and human in addition to cDNA-expressed human cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT) enzymes. Fourteen metabolites have been detected, and these constructions have been elucidated by liquid chromatography-tandem mass spectrometry.
5 preliminary metabolic pathways of rivoglitazone consisting of 4 oxidation pathways and one N-glucuronidation pathway have been predicted in correspondence with these proposed for in vivo research utilizing rats and monkeys. In metabolization utilizing liver microsomes, the TZD ring-opened mercapto amide (M22) and TZD ring-opened mercapto carboxylic acid (M23) have been recognized as the first metabolite of the TZD ring-opening pathway and its sequential metabolite, which haven’t been detected beforehand from in vivo research. Mixture with S-adenosyl-L-methionine was helpful to acquire the sequential S-methylated metabolites from the oxidative metabolites.
 Genomic DNA - Bovine Female |
|
D1B34999-G02 |
Biochain |
100 ug |
EUR 188 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
 Genomic DNA - Chicken Female |
|
D1C34999-G02 |
Biochain |
100 ug |
EUR 188 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
 Genomic DNA - Hamster Female |
|
D1H34999-G02 |
Biochain |
100 ug |
EUR 188 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
 Genomic DNA - Horse Female |
|
D1O34999-G02 |
Biochain |
100 ug |
EUR 188 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
 Genomic DNA - Cynomolgus Monkey Female |
|
D1534999-Cy-G02 |
Biochain |
100 ug |
EUR 188 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
 Genomic DNA - Rhesus Monkey Female |
|
D1534999-G02 |
Biochain |
100 ug |
EUR 188 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
 Genomic DNA - Guinea Pig Female |
|
D1G34999-G02 |
Biochain |
100 ug |
EUR 188 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
) Neurons (iPSC from Blood Cells; Female) |
|
ASE-9321F |
Applied StemCell |
1 vial (1 x 10^6) |
EUR 313.25 |
|
Description: 12 month |
 Liver Liver Cirrhosis Lysate |
|
XBL-10358 |
ProSci |
0.1 mg |
EUR 663.5 |
|
Description: Human liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human liver tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
 Rat Liver Tissue Lysate |
|
LYSATE0003 |
BosterBio |
200ug |
EUR 150 |
|
Description: This cell lysate is prepared from rat liver tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C. |
 Antibody) Rat Ferritin (Liver) Antibody |
|
11901-05011 |
AssayPro |
150 ug |
EUR 217 |
 Rat Liver PrimaCell: Hepatocytes |
|
2-82595 |
CHI Scientific |
1 Kit |
Ask for price |
 C-FLEX TUBING, 3'- 1/4" ID, WITH FEMALE MPC CONNECTOR TO FEMALE LUER W/CAP |
|
91-700-04 |
CORNING |
1/pk |
EUR 69 |
|
Description: Flexible Containers; Bioprocess Bags and Parts |
 cDNA from Liver Cirrhosis: Liver |
|
C1236149Lcs |
Biochain |
40 reactions |
EUR 668 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
 Liver Membrane Liver Cirrhosis Lysate |
|
XBL-10671 |
ProSci |
0.1 mg |
EUR 626.75 |
|
Description: Human liver tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human liver tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated liver tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated liver tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal. |
) Astrocytes Mature (iPSC from Blood Cells; Female) |
|
ASE-9322MF |
Applied StemCell |
1 vial (1 x 10^6) |
EUR 455 |
|
Description: 12 month |
) Astrocytes Precursors (iPSC from Blood Cells; Female) |
|
ASE-9322PF |
Applied StemCell |
1 vial (1 x 10^6) |
EUR 374 |
|
Description: 12 month |
) Dopaminergic Neurons (iPSC from Blood Cells; Female) |
|
ASE-9323F |
Applied StemCell |
1 vial |
EUR 374 |
|
Description: 12 month |
 Protein) Rat Phosphofructokinase, Liver (PFKL) Protein |
|
20-abx167625 |
Abbexa |
-
EUR 704.00
-
EUR 286.00
-
EUR 2165.00
-
EUR 829.00
-
EUR 495.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
 Rat Liver glycogen ELISA kit |
|
E02H0052-192T |
BlueGene |
192 tests |
EUR 1270 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Liver glycogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Liver glycogen ELISA kit |
|
E02H0052-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Liver glycogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Liver glycogen ELISA kit |
|
E02H0052-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Liver glycogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Total Protein from Liver Cirrhosis: Liver |
|
P1236149Lcs |
Biochain |
1 mg |
EUR 461 |
|
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
 Membrane Protein from Liver Cirrhosis: Liver |
|
P3236149Lcs |
Biochain |
0.1 mg |
EUR 408 |
|
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
 Total RNA from Liver Cirrhosis: Liver |
|
R1236149Lcs-50 |
Biochain |
50 ug |
EUR 351 |
|
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes. |
 Paraffin Tissue Section - Liver Cirrhosis: Liver |
|
T2236149Lcs |
Biochain |
5 slides |
EUR 257 |
|
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
 Liver Lysate |
|
1304 |
ProSci |
0.1 mg |
EUR 191 |
|
Description: Liver tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT. |
Liver Lysate |
|
1404 |
ProSci |
0.1 mg |
EUR 191 |
|
Description: Liver tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT. |
Liver Lysate |
|
1464 |
ProSci |
0.1 mg |
EUR 191 |
|
Description: Liver tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT. |
Liver Lysate |
|
21-105 |
ProSci |
0.1 mg |
EUR 285.5 |
|
Description: Bovine liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The bovine liver tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Liver Lysate |
|
21-302 |
ProSci |
0.1 mg |
EUR 285.5 |
|
Description: Monkey (Rhesus) liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The monkey (Rhesus) liver tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Liver Lysate |
|
21-406 |
ProSci |
0.1 mg |
EUR 285.5 |
|
Description: Porcine liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The porcine liver tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Liver Lysate |
|
21-419 |
ProSci |
0.1 mg |
EUR 285.5 |
|
Description: Rabbit liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The rabbit liver tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
) Neural Stem Cells (iPSC from Blood Cells; Female) |
|
ASE-9234F |
Applied StemCell |
1 vial (1 x 10^6) |
EUR 414.5 |
|
Description: 12 month |
) Neurons Starter Kit (iPSC from Blood Cells; Female) |
|
ASE-9321KF |
Applied StemCell |
1 Kit |
EUR 394.25 |
|
Description: 12 month |
, Rat) Liver Dissociation System 4 (Hepatocytes, rat), Rat |
|
4-20304 |
CHI Scientific |
ea |
Ask for price |
 Polyclonal Antibody (Rat)) Phosphofructokinase, Liver (PFKL) Polyclonal Antibody (Rat) |
|
4-PAD406Ra01 |
Cloud-Clone |
-
EUR 259.00
-
EUR 2708.00
-
EUR 670.00
-
EUR 328.00
-
EUR 219.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
|
|
Description: A Rabbit polyclonal antibody against Rat Phosphofructokinase, Liver (PFKL) |
 ELISA Kit) Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
|
SED406Ra-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 5124.2 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Phosphofructokinase, Liver (PFKL) in tissue homogenates, cell lysates and other biological fluids. |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
|
SED406Ra-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 509.64 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Phosphofructokinase, Liver (PFKL) in tissue homogenates, cell lysates and other biological fluids. |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
|
SED406Ra-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 685.2 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Phosphofructokinase, Liver (PFKL) in tissue homogenates, cell lysates and other biological fluids. |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
|
SED406Ra-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 2783.4 |
|
|
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Phosphofructokinase, Liver (PFKL) in tissue homogenates, cell lysates and other biological fluids. |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
|
4-SED406Ra |
Cloud-Clone |
-
EUR 5175.00
-
EUR 2734.00
-
EUR 686.00
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Phosphofructokinase, Liver (PFKL) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
) Rat Phosphofructokinase, Liver ELISA Kit (PFKL) |
|
RK03883 |
Abclonal |
96 Tests |
EUR 521 |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
|
RD-PFKL-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 557 |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
|
RD-PFKL-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 775 |
 Antibody (Biotin Conjugate)) Rat Ferritin (Liver) Antibody (Biotin Conjugate) |
|
11901-05021 |
AssayPro |
150 ug |
EUR 276 |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
|
DLR-PFKL-Ra-48T |
DL Develop |
48T |
EUR 549 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Rat Phosphofructokinase, Liver (PFKL) in samples from tissue homogenates, cell lysates or other biological fluids. |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
|
DLR-PFKL-Ra-96T |
DL Develop |
96T |
EUR 718 |
|
|
|
Description: A sandwich quantitative ELISA assay kit for detection of Rat Phosphofructokinase, Liver (PFKL) in samples from tissue homogenates, cell lysates or other biological fluids. |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
|
abx573958-96tests |
Abbexa |
96 tests |
EUR 739 |
|
|
 CLIA Kit) Rat Phosphofructokinase, Liver (PFKL) CLIA Kit |
|
20-abx494255 |
Abbexa |
-
EUR 8569.00
-
EUR 4560.00
-
EUR 1052.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
 Protein) Rat Glycogen Phosphorylase, Liver (PYGL) Protein |
|
20-abx066870 |
Abbexa |
-
EUR 704.00
-
EUR 286.00
-
EUR 2165.00
-
EUR 829.00
-
EUR 495.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
Rat Glycogen Phosphorylase, Liver (PYGL) Protein |
|
20-abx066872 |
Abbexa |
-
EUR 704.00
-
EUR 286.00
-
EUR 2165.00
-
EUR 829.00
-
EUR 495.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
Rat Glycogen Phosphorylase, Liver (PYGL) Protein |
|
20-abx066873 |
Abbexa |
-
EUR 704.00
-
EUR 286.00
-
EUR 2165.00
-
EUR 829.00
-
EUR 495.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
|
 Rat FibrOut 2, for cartilage, liver |
|
4-20529 |
CHI Scientific |
1 ml |
Ask for price |
Rat FibrOut 2, for cartilage, liver |
|
4-20530 |
CHI Scientific |
5 x 1 ml |
Ask for price |
 Rat Liver OptiTDS: Tissue Dissociation System |
|
4-28322 |
CHI Scientific |
1 Kit |
Ask for price |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
|
20-abx155968 |
Abbexa |
-
EUR 7237.00
-
EUR 3855.00
-
EUR 895.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
|
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
|
RDR-PFKL-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 583 |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
|
RDR-PFKL-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 811 |
 Rat Collectin Liver 1 ELISA kit |
|
E02C0405-192T |
BlueGene |
192 tests |
EUR 1270 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Collectin Liver 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Collectin Liver 1 ELISA kit |
|
E02C0405-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Collectin Liver 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Collectin Liver 1 ELISA kit |
|
E02C0405-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Collectin Liver 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Rat Glycogen Phosphorylase, Liver ELISA kit |
|
E02P0171-192T |
BlueGene |
192 tests |
EUR 1270 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Glycogen Phosphorylase, Liver in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Glycogen Phosphorylase, Liver ELISA kit |
|
E02P0171-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Glycogen Phosphorylase, Liver in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Glycogen Phosphorylase, Liver ELISA kit |
|
E02P0171-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
|
|
|
Description: A competitive ELISA for quantitative measurement of Rat Glycogen Phosphorylase, Liver in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 Rat Liver specific lipootein ELISA kit |
|
E02L0280-192T |
BlueGene |
192 tests |
EUR 1270 |
|
|
|
Description: A sandwich ELISA for quantitative measurement of Rat Liver specific lipootein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Liver specific lipootein ELISA kit |
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E02L0280-48 |
BlueGene |
1 plate of 48 wells |
EUR 520 |
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Description: A sandwich ELISA for quantitative measurement of Rat Liver specific lipootein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Liver specific lipootein ELISA kit |
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E02L0280-96 |
BlueGene |
1 plate of 96 wells |
EUR 685 |
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Description: A sandwich ELISA for quantitative measurement of Rat Liver specific lipootein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
 cDNA from Rat Normal Tissue: Liver |
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C1434149 |
Biochain |
40 reactions |
EUR 376 |
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Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
) Multiplex ELISA Kit For Human Female Hormone - (8-plex) |
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MEK1022 |
BosterBio |
1 kit |
EUR 1414 |
) Astrocytes Precursors Starter Kit (iPSC from Blood Cells; Female) |
|
ASE-9322PKF |
Applied StemCell |
1 Kit |
EUR 414.5 |
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Description: 12 month |
) Dopaminergic Neurons Starter Kit (iPSC from Blood Cells; Female) |
|
ASE-9323KF |
Applied StemCell |
1 vial |
EUR 455 |
|
Description: 12 month |
 Liver Cancer Exosome |
|
P141-LV |
101Bio |
- |
Ask for price |
 Liver Arginase Antibody |
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49867-100ul |
SAB |
100ul |
EUR 333 |
Liver Arginase Antibody |
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49867-50ul |
SAB |
50ul |
EUR 239 |
) Chang Liver (HeLa) |
|
C0050007 |
Addexbio |
One Frozen vial |
EUR 543 |
 CK LIVER 1kg* |
|
43023-2 |
Pel-Freez |
1 kg |
EUR 240.09 |
 Liver Ferritin Protein |
|
20-abx260074 |
Abbexa |
-
EUR 2903.00
-
EUR 648.00
-
EUR 286.00
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 liver Arginase Antibody |
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abx234800-100ug |
Abbexa |
100 ug |
EUR 481 |
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liver Arginase Antibody |
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abx234801-100ug |
Abbexa |
100 ug |
EUR 481 |
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 anti-liver Arginase |
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YF-PA10306 |
Abfrontier |
50 ug |
EUR 363 |
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Description: Mouse polyclonal to liver Arginase |
anti-liver Arginase |
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YF-PA10307 |
Abfrontier |
50 ug |
EUR 363 |
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Description: Mouse polyclonal to liver Arginase |
anti-liver Arginase |
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YF-PA10308 |
Abfrontier |
100 ul |
EUR 403 |
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Description: Rabbit polyclonal to liver Arginase |
anti-liver Arginase |
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YF-PA10309 |
Abfrontier |
100 ug |
EUR 403 |
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Description: Rabbit polyclonal to liver Arginase |
 anti-liver FABP |
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YF-PA11679 |
Abfrontier |
50 ul |
EUR 363 |
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Description: Mouse polyclonal to liver FABP |
N-Glucuronide and sequential TZD ring-opened metabolites have been additionally present in liver microsomes within the presence of UDP-glucuronic acid. The O-demethyl-O-sulfate (M11), which is the main in vivo metabolite in rats and monkeys, was detected in all species of hepatocytes. As well as, a TZD ring-opened S-cysteine conjugate (M15) was detected in human hepatocytes. From these outcomes, the in vivo metabolic pathways in people have been predicted to be the 4 oxidation and one N-glucuronidation pathways. The 4 oxidative metabolites have been fashioned by a number of human P450 enzymes, and N-glucuronide was fashioned by UGT1A3 and UGT2B7.
