Within the current examine, the in vitro metabolic habits of a benzopyridooxathiazepine (BZN), a potent tubulin polymerization inhibitor, was investigated by liquid chromatography-UV detection (LC-UV). First, easy and quick LC-UV strategies have been optimized and validated to judge the pharmacokinetic profile of BZN utilizing rat liver microsomes or hepatocytes main cultures suspensions. Regardless of the medium investigated, baseline decision between the interior commonplace and BZN was achieved in a run time lower than 15min utilizing a Symmetry ODS column (150mm×4.6mm i.d., 5μm) and a cell part consisting of acetonitrile/water/formic acid 60:40:0.1 (v/v/v). Linearity was assessed within the 0.1-50μM and within the 0.05-5μM focus ranges, respectively, in microsomal and hepatocyte matrix.
Based on the novel technique based mostly on the construct of the accuracy profile, whole error of the developed strategies was included inside the ±10% limits of acceptance. Then, from incubation of BZN with each liver microsomes and or hepatocytes, structural informations on part I and part II metabolites have been acquired utilizing liquid chromatography coupled to electrospray orbitrap mass spectrometer (LC-MS). Mass spectrum, double bond equal and elemental composition have been helpful knowledge to entry to the chemical construction of every metabolite.
In microsomal suspension, 4 predominant metabolites have been noticed together with monohydroxylation and dihydroxylation of the benzopyridooxathiazepine core, demethylation of the methoxyphenyl moiety, in addition to their mixtures. The part II metabolites detected in hepatocytes suspension have been the glucuronide adducts of each demethylated BZN and mono-oxygenated BZN. Primarily based on the structural elucidation of the metabolites detected, we proposed an in vitro metabolic pathway of BZN, a brand new tubulin polymerization inhibitor.
In vitro metabolism of BIIB021, an inhibitor of warmth shock protein 90, in liver microsomes and hepatocytes of rats, canines, and people and recombinant human cytochrome P450 isoforms.
Inhibition of warmth shock protein 90 (HSP90) ends in the degradation of oncoproteins that drive malignant development and induce cell loss of life, thus making HSP90 a possible goal of most cancers remedy. 6-Chloro-9-(4-methoxy-3, 5-dimethyl-pyridin-2-ylmethyl)-9H-purin-2-ylamine (BIIB021), an artificial HSP90 inhibitor, exhibited promising antitumor exercise in preclinical fashions. It’s at present in part II medical trials for the oral remedy of breast most cancers. The target of this examine was to acquire each quantitative and qualitative metabolic profiles of [(14)C]BIIB021 in rat, canine, and human liver microsomes and hepatocytes to supply assist for in vivo security and medical research.
The metabolites of [(14)C]BIIB021 have been recognized utilizing liquid chromatography-tandem mass spectrometry coupled with radiometric detection. BIIB021 was extensively metabolized in each liver microsomes and hepatocytes. The foremost oxidative metabolic pathways recognized for all species have been attributable to hydroxylation (M7) and O-demethylation (M2) of the methoxy-dimethylpyridine moiety. The vast majority of M7 in canine hepatocytes was additional conjugated to type the glucuronide (M4). Oxidative dechlorination (M6), monooxygenation (M10), and oxidative N-dealkylation of the methoxy-dimethylpyridine moiety (M11 and M12) have been noticed because the minor metabolic pathways in hepatocytes of all three species. A glutathione conjugate (M18) was additionally recognized in all species.
Its formation was catalyzed, partially, by soluble glutathione transferase by way of direct displacement of the chlorine on the amino-chloropurine moiety. Subsequent minor secondary metabolites M13, M14, M15, and M17 have been noticed in human, canine, and rat hepatocytes. Outcomes from incubations of BIIB021 with human recombinant cytochrome P450 (P450) isoforms and a P450 antibody inhibition examine in human liver microsomes urged that the formation of M7 is especially catalyzed by CYP2C19 and CYP3A4, whereas the formation of minor metabolite M2 in human liver microsomes most likely may very well be attributed to CYP3A4.
In vitro metabolism of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rat, monkey, and human liver microsomes and freshly remoted hepatocytes.
The in vitro metabolism of rivoglitazone, (RS)-5-{4-[(6-methoxy-1-methyl-1H-benzimidazol-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione monohydrochloride, a novel thiazolidinedione (TZD) peroxisome proliferator-activated receptor γ selective agonist, was studied in liver microsomes and freshly remoted hepatocytes of rat, monkey, and human in addition to cDNA-expressed human cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT) enzymes. Fourteen metabolites have been detected, and these constructions have been elucidated by liquid chromatography-tandem mass spectrometry.
5 preliminary metabolic pathways of rivoglitazone consisting of 4 oxidation pathways and one N-glucuronidation pathway have been predicted in correspondence with these proposed for in vivo research utilizing rats and monkeys. In metabolization utilizing liver microsomes, the TZD ring-opened mercapto amide (M22) and TZD ring-opened mercapto carboxylic acid (M23) have been recognized as the first metabolite of the TZD ring-opening pathway and its sequential metabolite, which haven’t been detected beforehand from in vivo research. Mixture with S-adenosyl-L-methionine was helpful to acquire the sequential S-methylated metabolites from the oxidative metabolites.
Serum, Rat, Sprague Dawley, Female |
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| MBS638869-25mL | MyBiosource | 25mL | EUR 710 |
Serum, Rat, Sprague Dawley, Female |
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| MBS638869-50mL | MyBiosource | 50mL | EUR 1035 |
Serum, Rat, Sprague Dawley, Female |
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| MBS638869-5x50mL | MyBiosource | 5x50mL | EUR 4430 |
*Rat Renin Substrate Plasma Female |
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| IRTRENSPF10ML | Innovative research | each | EUR 4211 |
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Description: *Rat Renin Substrate Plasma Female |
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*Rat Renin Substrate Plasma Female |
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| IRTRENSPF1ML | Innovative research | each | EUR 528 |
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Description: *Rat Renin Substrate Plasma Female |
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Kinesis Female Luer - Female union 1/8 - EACH |
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| CHR4263 | Scientific Laboratory Supplies | EACH | EUR 13.5 |
Kinesis Adapter 10.32 Female to 1/4-28 Female - EACH |
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| CHR4259 | Scientific Laboratory Supplies | EACH | EUR 43.2 |
Kinesis Adapter Female luer to Female 10-32 ETFE - EACH |
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| CHR4267 | Scientific Laboratory Supplies | EACH | EUR 8.1 |
Rat Long Evans Genomic DNA, Female |
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| GRL-180F | Zyagen | 0.1mg | EUR 177 |
Rat Sprague Dawley Genomic DNA, Female |
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| GRS-180F | Zyagen | 0.1mg | EUR 177 |
Kinesis Luer Adapter Female x 1/4-28 Female Tefzel - EACH |
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| CHR4353 | Scientific Laboratory Supplies | EACH | EUR 13.5 |
Kinesis Adapter Female luer to 10-32 Female PEEK - EACH |
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| CHR4315 | Scientific Laboratory Supplies | EACH | EUR 33.75 |
Kinesis Adapter Luer Female to M6 Female; Black PEEK - EACH |
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| CHR4317 | Scientific Laboratory Supplies | EACH | EUR 25.65 |
Kinesis Adapter 5/16-24 Female to 1/2-20 Female PEEK - EACH |
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| CHR5095 | Scientific Laboratory Supplies | EACH | EUR 87.75 |
Kinesis Adaptor 5/16-24 Female To 1/4-28 Female; PEEK - EACH |
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| CHR3793 | Scientific Laboratory Supplies | EACH | EUR 31.05 |
Kinesis Adaptor Body 1/2-20 Female x 1/4-28 Female - EACH |
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| CHR5105 | Scientific Laboratory Supplies | EACH | EUR 62.1 |
Urine, Human, Female |
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| MBS641014-50mL | MyBiosource | 50mL | EUR 485 |
Urine, Human, Female |
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| MBS641014-5x50mL | MyBiosource | 5x50mL | EUR 1960 |
Rat Renin Substrate Plasma, Female, Sodium EDTA |
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| MBS135600-10mL | MyBiosource | 10mL | EUR 5230 |
Rat Renin Substrate Plasma, Female, Sodium EDTA |
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| MBS135600-1mL | MyBiosource | 1mL | EUR 750 |
Female FPLC Connector |
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| FFC-1 | Agarose Bead Technologies | 1 | EUR 43.86 |
Dog Genomic DNA, Female |
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| GD-150F | Zyagen | 0.1mg | EUR 177 |
Human Genomic DNA, female |
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| GH-180F | Zyagen | 0.1mg | EUR 177 |
Sheep Genomic DNA, Female |
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| GS-190F | Zyagen | 0.1mg | EUR 177 |
Rabbit Genomic DNA, Female |
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| GR-170F | Zyagen | 0.1mg | EUR 177 |
Bovine Genomic DNA , Female |
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| GB-110F | Zyagen | 0.1mg | EUR 177 |
Female Nut BSPP R/H |
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| GAS1086 | Scientific Laboratory Supplies | EACH | EUR 23.14 |
Chicken Genomic DNA, Female |
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| GC-120F | Zyagen | 0.1mg | EUR 177 |
Porcine Genomic DNA, Female |
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| GP-160F | Zyagen | 0.1mg | EUR 177 |
Fecal Matter - Normal - Female |
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| MBS170591-10Samples | MyBiosource | 10Samples | EUR 2360 |
Fecal Matter - Normal - Female |
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| MBS170591-1Sample | MyBiosource | 1Sample | EUR 425 |
Fecal Matter - Normal - Female |
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| MBS170591-5x10Samples | MyBiosource | 5x10Samples | EUR 10405 |
C-FLEX TUBING, 3'- 1/4" ID, WITH FEMALE MPC CONNECTOR TO FEMALE LUER W/CAP |
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| 91-700-04 | CORNING | 1/pk | EUR 82.8 |
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Description: Flexible Containers; Bioprocess Bags and Parts |
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Serum, Monkey, Cynomolgus, Female |
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| MBS638816-10mL | MyBiosource | 10mL | EUR 440 |
Serum, Monkey, Cynomolgus, Female |
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| MBS638816-25mL | MyBiosource | 25mL | EUR 870 |
Serum, Monkey, Cynomolgus, Female |
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| MBS638816-50mL | MyBiosource | 50mL | EUR 1350 |
Serum, Monkey, Cynomolgus, Female |
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| MBS638816-5x50mL | MyBiosource | 5x50mL | EUR 5845 |
Control Genomic DNA - Dog Female |
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| D1734999-G02 | Biochain | 100 ug | EUR 196 |
Buccal Swab, Female Human Donor |
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| MBS170497-1Sample | MyBiosource | 1Sample | EUR 260 |
Buccal Swab, Female Human Donor |
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| MBS170497-5Samples | MyBiosource | 5Samples | EUR 675 |
Buccal Swab, Female Human Donor |
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| MBS170497-5x5Samples | MyBiosource | 5x5Samples | EUR 2820 |
Frog Xenopus Genomic DNA. Female |
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| GF-240F | Zyagen | 0.1mg | EUR 177 |
Sweat, Single Human Female Donor |
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| MBS170262-1Sample | MyBiosource | 1Sample | EUR 310 |
Sweat, Single Human Female Donor |
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| MBS170262-5Samples | MyBiosource | 5Samples | EUR 1005 |
Sweat, Single Human Female Donor |
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| MBS170262-5x5Samples | MyBiosource | 5x5Samples | EUR 4310 |
Rat Cytochrome P450 2C12, female-specific (CYP2C12) ELISA Kit |
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| abx508262-96tests | Abbexa | 96 tests | EUR 687.5 |
Control Genomic DNA - Human Female |
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| D1234999-G02 | Biochain | 100 ug | EUR 196 |
Control Genomic DNA - Mouse Female |
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| D1334999-G02 | Biochain | 100 ug | EUR 196 |
Control Genomic DNA - Horse Female |
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| D1O34999-G02 | Biochain | 100 ug | EUR 196 |
Kinesis Female Luer Fittings - PK2 |
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| CHR1247 | Scientific Laboratory Supplies | PK2 | EUR 8.1 |
Saliva, Single Female Human Donor |
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| MBS170210-1Sample | MyBiosource | 1Sample | EUR 210 |
Saliva, Single Female Human Donor |
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| MBS170210-5Samples | MyBiosource | 5Samples | EUR 470 |
Saliva, Single Female Human Donor |
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| MBS170210-5x5Samples | MyBiosource | 5x5Samples | EUR 1905 |
Normal Urine, Single Female Donor |
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| MBS170218-100Samples | MyBiosource | 100Samples | EUR 5905 |
Normal Urine, Single Female Donor |
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| MBS170218-10Samples | MyBiosource | 10Samples | EUR 820 |
Normal Urine, Single Female Donor |
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| MBS170218-1Sample | MyBiosource | 1Sample | EUR 220 |
Normal Urine, Single Female Donor |
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| MBS170218-5x100Samples | MyBiosource | 5x100Samples | EUR 26355 |
Vaginal Swabs, Female Human Donor |
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| MBS170495-1Sample | MyBiosource | 1Sample | EUR 330 |
Vaginal Swabs, Female Human Donor |
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| MBS170495-3Samples | MyBiosource | 3Samples | EUR 680 |
Vaginal Swabs, Female Human Donor |
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| MBS170495-5x3Samples | MyBiosource | 5x3Samples | EUR 2855 |
Control Genomic DNA - Rabbit Female |
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| D1834999-G02 | Biochain | 100 ug | EUR 196 |
Control Genomic DNA - Bovine Female |
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| D1B34999-G02 | Biochain | 100 ug | EUR 196 |
Vaginal Fluid, Single Female Donor |
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| MBS170232-01mL | MyBiosource | 0.1mL | EUR 680 |
Vaginal Fluid, Single Female Donor |
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| MBS170232-025mL | MyBiosource | 0.25mL | EUR 995 |
Vaginal Fluid, Single Female Donor |
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| MBS170232-10mL | MyBiosource | 10mL | EUR 6340 |
Vaginal Fluid, Single Female Donor |
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| MBS170232-1mL | MyBiosource | 1mL | EUR 2125 |
Vaginal Fluid, Single Female Donor |
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| MBS170232-5x10mL | MyBiosource | 5x10mL | EUR 28320 |
Recombinant Rat Meiosis arrest female protein 1 (Marf1) , partial |
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| MBS1316123-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Tissue, Control Genomic DNA, Rat Adult Normal, Female, BioGenomics |
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| MBS654404-01mg | MyBiosource | 0.1mg | EUR 460 |
Tissue, Control Genomic DNA, Rat Adult Normal, Female, BioGenomics |
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| MBS654404-5x01mg | MyBiosource | 5x0.1mg | EUR 1925 |
HUMAN, SERUM, FEMALE, UNFILTERED, UNIT |
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| 7323801 | Lampire Biologicals Laboratories | 1UNIT | EUR 728.2 |
Control Genomic DNA - Porcine Female |
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| D1934999-G02 | Biochain | 100 ug | EUR 196 |
Control Genomic DNA - Chicken Female |
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| D1C34999-G02 | Biochain | 100 ug | EUR 196 |
Control Genomic DNA - Hamster Female |
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| D1H34999-G02 | Biochain | 100 ug | EUR 196 |
Hamster, Chinese, Genomic DNA, Female* |
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| GA-170CF | Zyagen | 0.05mg | EUR 177 |
Salmon, Atlantic Genomic DNA, Female |
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| GFS-190F | Zyagen | 0.05mg | EUR 177 |
Hamster, Armenian, Genomic DNA, Female |
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| GA-170AF | Zyagen | 0.1mg | EUR 177 |
RAT, WISTAR, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 100 ML |
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| 7368300-100ML | Lampire Biologicals Laboratories | 1ML | EUR 223.75 |
RAT, WISTAR, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 25 ML |
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| 7368300-25ML | Lampire Biologicals Laboratories | 1ML | EUR 89.06 |
RAT, WISTAR, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 500 ML |
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| 7368300-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1053.9 |
RAT, WISTAR, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 50 ML |
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| 7368300-50ML | Lampire Biologicals Laboratories | 1ML | EUR 127.12 |
Mouse BALB/C Genomic DNA, Female |
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| GMB-150F | Zyagen | 0.1mg | EUR 177 |
Mouse ICR (CD1) Genomic DNA, Female |
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| GMI-150F | Zyagen | 0.1mg | EUR 177 |
Human Mammary Epithelial Cells, Female |
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| ABC-TC3692 | AcceGen | 1 vial | Ask for price |
|
Description: Human Mammary Epithelial Cells, when grown in LIMam Medium, provide an ideal serum-free culture model for many areas of research. Common uses of HMEC include the stages of breast cancer development, three dimensional culture and carcinogen screening.Cell Features:HMEC are cryopreserved as tertiary cells, e.g. cells are isolated from human mammary tissue and expanded three times in culture vessels before being harvested for cryopreservation.HMEC are extensively tested for quality and optimal performance.Gentaur guarantees performance and quality. |
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Mouse C57BL/6J Genomic DNA, Female |
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| GMC-150F | Zyagen | 0.1mg | EUR 177 |
Female Nut BSPP L/H 6mm - EACH |
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| GAS1092 | Scientific Laboratory Supplies | EACH | EUR 17.26 |
FBS - Female Only Fetal Bovine Serum |
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| FBS001-F | Neuromics | each | EUR 581.4 |
Human Hepatocytes-Single Donor, Female |
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| ABC-TC3647 | AcceGen | 1 vial | Ask for price |
|
Description: Gentaur's hepatocytes for suspension assays (HP1 Heps-s, single donor, female) provide an economic source of characterized human hepatocytes for use in short-term suspension assays to evaluate the metabolism of drug candidates. Gentaur's hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available. |
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Female reproductive system tissue array |
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| FRS801 | TissueArray | each | EUR 306 |
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Description: Female reproductive system tissue array, with stage and grade info, 80 cases/80 cores |
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Neurons (iPSC from Blood Cells; Female) |
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| ASE-9321F | Applied StemCell | 1 vial (1 x 10^6) | EUR 375.9 |
|
Description: 12 month |
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Age grouped female skin tissue array |
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| SK244a | TissueArray | each | EUR 270 |
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Description: Age grouped female skin tissue array, 12 cases/24 cores, replacing SK244 |
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Control Genomic DNA - Guinea Pig Female |
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| D1G34999-G02 | Biochain | 100 ug | EUR 196 |
Single Donor Human Female Rectal Swab |
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| IRHUSRCTSWBFEM1 | Innovative research | each | EUR 428 |
|
Description: Single Donor Human Female Rectal Swab |
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Kinesis Female Nut (Micro Fittings) - EACH |
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| CHR4137 | Scientific Laboratory Supplies | EACH | EUR 13.5 |
Single Donor Human Female Fecal Matter |
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| IRHUFSMFEM1 | Innovative research | each | EUR 382 |
|
Description: Single Donor Human Female Fecal Matter |
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Single Donor Human Female Fecal Matter |
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| IRHUFSMFEM5 | Innovative research | each | EUR 3566 |
|
Description: Single Donor Human Female Fecal Matter |
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Single Donor Human Female Fecal Matter |
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| MBS8421276-INQUIRE | MyBiosource | INQUIRE | Ask for price |
RAT, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 100 ML |
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| 7347101-100ML | Lampire Biologicals Laboratories | 1ML | EUR 247.18 |
RAT, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 25 ML |
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| 7347101-25ML | Lampire Biologicals Laboratories | 1ML | EUR 96.38 |
RAT, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 500 ML |
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| 7347101-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1163.71 |
RAT, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 50 ML |
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| 7347101-50ML | Lampire Biologicals Laboratories | 1ML | EUR 141.76 |
RAT, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 100 ML |
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| 7347104-100ML | Lampire Biologicals Laboratories | 1ML | EUR 247.18 |
RAT, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 25 ML |
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| 7347104-25ML | Lampire Biologicals Laboratories | 1ML | EUR 96.38 |
RAT, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 500 ML |
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| 7347104-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1163.71 |
RAT, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 50 ML |
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| 7347104-50ML | Lampire Biologicals Laboratories | 1ML | EUR 141.76 |
Kinesis Luer Female - 1/8in Barb - EACH |
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| CHR4593 | Scientific Laboratory Supplies | EACH | EUR 2.7 |
Control Genomic DNA - Rhesus Monkey Female |
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| D1534999-G02 | Biochain | 100 ug | EUR 196 |
Hamster, Syrian Golden, Genomic DNA, Female |
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| GA-170F | Zyagen | 0.1mg | EUR 177 |
Single Donor Human Female Perianal Swabs |
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| IRHUSPANSWBFEM1 | Innovative research | each | EUR 763 |
|
Description: Single Donor Human Female Perianal Swabs |
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Single Donor Human Female Perianal Swabs |
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| IRHUSPANSWBFEM5 | Innovative research | each | EUR 3809 |
|
Description: Single Donor Human Female Perianal Swabs |
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Single Donor Human Female Perianal Swabs |
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| MBS8421304-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Kinesis Luer Female - 3/32in Barb - EACH |
|||
| CHR4591 | Scientific Laboratory Supplies | EACH | EUR 4.05 |
Kinesis Siltite Fingertight Female Nut - PK5 |
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| CHR1941 | Scientific Laboratory Supplies | PK5 | EUR 153.9 |
RAT, SPRAGUE DAWLEY, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 100 ML |
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| 7368000-100ML | Lampire Biologicals Laboratories | 1ML | EUR 204.72 |
RAT, SPRAGUE DAWLEY, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 25 ML |
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| 7368000-25ML | Lampire Biologicals Laboratories | 1ML | EUR 89.06 |
RAT, SPRAGUE DAWLEY, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 500 ML |
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| 7368000-500ML | Lampire Biologicals Laboratories | 1ML | EUR 821.11 |
RAT, SPRAGUE DAWLEY, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 50 ML |
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| 7368000-50ML | Lampire Biologicals Laboratories | 1ML | EUR 127.12 |
RAT, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 100 ML |
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| 7347103-100ML | Lampire Biologicals Laboratories | 1ML | EUR 247.18 |
RAT, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 25 ML |
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| 7347103-25ML | Lampire Biologicals Laboratories | 1ML | EUR 96.38 |
RAT, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 500 ML |
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| 7347103-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1163.71 |
RAT, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 50 ML |
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| 7347103-50ML | Lampire Biologicals Laboratories | 1ML | EUR 141.76 |
Recombinant Cricetulus migratorius Female protein |
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| MBS1126780-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1130 |
Recombinant Cricetulus migratorius Female protein |
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| MBS1126780-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 715 |
Recombinant Cricetulus migratorius Female protein |
|||
| MBS1126780-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 885 |
Recombinant Cricetulus migratorius Female protein |
|||
| MBS1126780-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 860 |
Recombinant Cricetulus migratorius Female protein |
|||
| MBS1126780-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1035 |
Kinesis Female Luer - M6 Tefzel Black - EACH |
|||
| CHR4363 | Scientific Laboratory Supplies | EACH | EUR 9.45 |
Single Donor Human Female Rectal Swab 1 |
|||
| MBS8421307-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Control Genomic DNA - Cynomolgus Monkey Female |
|||
| D1534999-Cy-G02 | Biochain | 100 ug | EUR 196 |
RAT, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 100 ML |
|||
| 7347107-100ML | Lampire Biologicals Laboratories | 1ML | EUR 247.18 |
RAT, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 25 ML |
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| 7347107-25ML | Lampire Biologicals Laboratories | 1ML | EUR 96.38 |
RAT, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 500 ML |
|||
| 7347107-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1163.71 |
RAT, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 50 ML |
|||
| 7347107-50ML | Lampire Biologicals Laboratories | 1ML | EUR 141.76 |
RAT, CONTROL PLASMA, NON DOMESTIC, K3 EDTA, DONOR, FEMALE, UNFILTERED, 100 ML |
|||
| 7347108-100ML | Lampire Biologicals Laboratories | 1ML | EUR 247.18 |
RAT, CONTROL PLASMA, NON DOMESTIC, K3 EDTA, DONOR, FEMALE, UNFILTERED, 25 ML |
|||
| 7347108-25ML | Lampire Biologicals Laboratories | 1ML | EUR 96.38 |
RAT, CONTROL PLASMA, NON DOMESTIC, K3 EDTA, DONOR, FEMALE, UNFILTERED, 500 ML |
|||
| 7347108-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1163.71 |
RAT, CONTROL PLASMA, NON DOMESTIC, K3 EDTA, DONOR, FEMALE, UNFILTERED, 50 ML |
|||
| 7347108-50ML | Lampire Biologicals Laboratories | 1ML | EUR 141.76 |
RAT, CONTROL PLASMA, NON DOMESTIC, NA EDTA, DONOR, FEMALE, UNFILTERED, 100 ML |
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| 7347109-100ML | Lampire Biologicals Laboratories | 1ML | EUR 247.18 |
RAT, CONTROL PLASMA, NON DOMESTIC, NA EDTA, DONOR, FEMALE, UNFILTERED, 25 ML |
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| 7347109-25ML | Lampire Biologicals Laboratories | 1ML | EUR 96.38 |
RAT, CONTROL PLASMA, NON DOMESTIC, NA EDTA, DONOR, FEMALE, UNFILTERED, 500 ML |
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| 7347109-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1163.71 |
RAT, CONTROL PLASMA, NON DOMESTIC, NA EDTA, DONOR, FEMALE, UNFILTERED, 50 ML |
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| 7347109-50ML | Lampire Biologicals Laboratories | 1ML | EUR 141.76 |
Female reproductive system tumor tissue array |
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| FE951 | TissueArray | each | EUR 354 |
|
Description: Female reproductive system tumor tissue array, including pathology grade, TNM and clinical stage (AJCC 8.0), 95 cases/95 cores (core size 1.5mm), Recent Year Collection |
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Kinesis 10-32 Female to Male Luer Nut - EACH |
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| CHR4311 | Scientific Laboratory Supplies | EACH | EUR 18.9 |
Kinesis Female Luer to MicroTight Body - EACH |
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| CHR4323 | Scientific Laboratory Supplies | EACH | EUR 85.05 |
RAT, CONTROL PLASMA, NON DOMESTIC, NA CITRATE, DONOR, FEMALE, UNFILTERED, 100 ML |
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| 7347106-100ML | Lampire Biologicals Laboratories | 1ML | EUR 247.18 |
RAT, CONTROL PLASMA, NON DOMESTIC, NA CITRATE, DONOR, FEMALE, UNFILTERED, 25 ML |
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| 7347106-25ML | Lampire Biologicals Laboratories | 1ML | EUR 96.38 |
RAT, CONTROL PLASMA, NON DOMESTIC, NA CITRATE, DONOR, FEMALE, UNFILTERED, 500 ML |
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| 7347106-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1163.71 |
RAT, CONTROL PLASMA, NON DOMESTIC, NA CITRATE, DONOR, FEMALE, UNFILTERED, 50 ML |
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| 7347106-50ML | Lampire Biologicals Laboratories | 1ML | EUR 141.76 |
RAT, CONTROL PLASMA, NON DOMESTIC, LI HEPARIN, DONOR, FEMALE, UNFILTERED, 100 ML |
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| 7347110-100ML | Lampire Biologicals Laboratories | 1ML | EUR 247.18 |
RAT, CONTROL PLASMA, NON DOMESTIC, LI HEPARIN, DONOR, FEMALE, UNFILTERED, 25 ML |
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| 7347110-25ML | Lampire Biologicals Laboratories | 1ML | EUR 96.38 |
RAT, CONTROL PLASMA, NON DOMESTIC, LI HEPARIN, DONOR, FEMALE, UNFILTERED, 500 ML |
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| 7347110-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1163.71 |
RAT, CONTROL PLASMA, NON DOMESTIC, LI HEPARIN, DONOR, FEMALE, UNFILTERED, 50 ML |
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| 7347110-50ML | Lampire Biologicals Laboratories | 1ML | EUR 141.76 |
RAT, CONTROL PLASMA, NON DOMESTIC, NA HEPARIN, DONOR, FEMALE, UNFILTERED, 100 ML |
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| 7347111-100ML | Lampire Biologicals Laboratories | 1ML | EUR 247.18 |
RAT, CONTROL PLASMA, NON DOMESTIC, NA HEPARIN, DONOR, FEMALE, UNFILTERED, 25 ML |
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| 7347111-25ML | Lampire Biologicals Laboratories | 1ML | EUR 96.38 |
RAT, CONTROL PLASMA, NON DOMESTIC, NA HEPARIN, DONOR, FEMALE, UNFILTERED, 500 ML |
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| 7347111-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1163.71 |
RAT, CONTROL PLASMA, NON DOMESTIC, NA HEPARIN, DONOR, FEMALE, UNFILTERED, 50 ML |
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| 7347111-50ML | Lampire Biologicals Laboratories | 1ML | EUR 141.76 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 100 ML |
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| 7348301-100ML | Lampire Biologicals Laboratories | 1ML | EUR 231.07 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 25 ML |
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| 7348301-25ML | Lampire Biologicals Laboratories | 1ML | EUR 96.38 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 500 ML |
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| 7348301-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1061.22 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 50 ML |
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| 7348301-50ML | Lampire Biologicals Laboratories | 1ML | EUR 141.76 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 100 ML |
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| 7348304-100ML | Lampire Biologicals Laboratories | 1ML | EUR 231.07 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 25 ML |
|||
| 7348304-25ML | Lampire Biologicals Laboratories | 1ML | EUR 96.38 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 500 ML |
|||
| 7348304-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1061.22 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 50 ML |
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| 7348304-50ML | Lampire Biologicals Laboratories | 1ML | EUR 141.76 |
Kinesis Adapter SS 10.32 Female to 1/4-28 Male - EACH |
|||
| CHR2347 | Scientific Laboratory Supplies | EACH | EUR 40.5 |
Serum - Plasma Derived Serum Units - Female Only |
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| MBS173719-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Human Hepatocytes-Single Donor, Female; Inducible |
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| ABC-TC3648 | AcceGen | 1 vial | Ask for price |
|
Description: Gentaur's inducible hepatocytes (HP1 Heps-i, single donor, female) can be plated and used in long-term drug induction studies or metabolic studies where long-term incubations are required. Gentaur's cryopreserved primary human hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is tested for plating and provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available. |
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Kinesis Adapter PEEK 10.32 Female to 1/4-28 Male - EACH |
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| CHR4333 | Scientific Laboratory Supplies | EACH | EUR 43.2 |
Normal female dog multiple organs tissue array |
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| DGF281 | TissueArray | each | EUR 306 |
|
Description: Normal female dog multiple organs tissue array, 28 organs/ 28cores |
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Astrocytes Mature (iPSC from Blood Cells; Female) |
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| ASE-9322MF | Applied StemCell | 1 vial (1 x 10^6) | EUR 546 |
|
Description: 12 month |
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Human Niemann Pick Type C (Female) iPS Cells |
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| CR1013-500 | celleng-tech | 1 vial | EUR 1050 |
|
Description: Cryopreserved vial of induced pluripotent stem cells from a single female donor with Niemann-Pick disease type C (500,000 cells) |
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Adapter X2 M30x1.5 female to NPT 3/4" male |
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| 8890083 | Scientific Laboratory Supplies | PK2 | EUR 239.8 |
Kinesis Luer Assembly M6 Female to Male - EACH |
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| CHR4313 | Scientific Laboratory Supplies | EACH | EUR 27 |
V-Neck Polycotton Lab Coat - Female - 100cm/40in - Medium - EACH |
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| SAF0078 | Scientific Laboratory Supplies | EACH | EUR 68.85 |
Kinesis Female Luer Fitting System - 1/8 - EACH |
|||
| CHR4545 | Scientific Laboratory Supplies | EACH | EUR 8.1 |
Kinesis Female Luer Fitting System - 1/16 - EACH |
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| CHR4553 | Scientific Laboratory Supplies | EACH | EUR 8.1 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 100 ML |
|||
| 7348303-100ML | Lampire Biologicals Laboratories | 1ML | EUR 231.07 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 25 ML |
|||
| 7348303-25ML | Lampire Biologicals Laboratories | 1ML | EUR 96.38 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 500 ML |
|||
| 7348303-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1061.22 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 50 ML |
|||
| 7348303-50ML | Lampire Biologicals Laboratories | 1ML | EUR 141.76 |
Kinesis Female Nut 5/16-24 PEEK Black - EACH |
|||
| CHR4139 | Scientific Laboratory Supplies | EACH | EUR 13.5 |
Kinesis Female Luer to 10-32 Male PEEK - EACH |
|||
| CHR4419 | Scientific Laboratory Supplies | EACH | EUR 52.65 |
Dopaminergic Neurons (iPSC from Blood Cells; Female) |
|||
| ASE-9323F | Applied StemCell | 1 vial | EUR 448.8 |
|
Description: 12 month |
|||
Neural Stem Cells (iPSC from Blood Cells; Female) |
|||
| ASE-9234F | Applied StemCell | 1 vial (1 x 10^6) | EUR 497.4 |
|
Description: 12 month |
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RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 100 ML |
|||
| 7348307-100ML | Lampire Biologicals Laboratories | 1ML | EUR 231.07 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 25 ML |
|||
| 7348307-25ML | Lampire Biologicals Laboratories | 1ML | EUR 96.38 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 500 ML |
|||
| 7348307-500ML | Lampire Biologicals Laboratories | 1ML | EUR 1061.22 |
RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 50 ML |
|||
| 7348307-50ML | Lampire Biologicals Laboratories | 1ML | EUR 141.76 |
N-Glucuronide and sequential TZD ring-opened metabolites have been additionally present in liver microsomes within the presence of UDP-glucuronic acid. The O-demethyl-O-sulfate (M11), which is the main in vivo metabolite in rats and monkeys, was detected in all species of hepatocytes. As well as, a TZD ring-opened S-cysteine conjugate (M15) was detected in human hepatocytes. From these outcomes, the in vivo metabolic pathways in people have been predicted to be the 4 oxidation and one N-glucuronidation pathways. The 4 oxidative metabolites have been fashioned by a number of human P450 enzymes, and N-glucuronide was fashioned by UGT1A3 and UGT2B7.
