In vitro pharmacokinetic profile of a benzopyridooxathiazepine derivative using rat microsomes and hepatocytes: identification of phases I and II metabolites.

In vitro pharmacokinetic profile of a benzopyridooxathiazepine derivative using rat microsomes and hepatocytes: identification of phases I and II metabolites. post thumbnail image

Within the current examine, the in vitro metabolic habits of a benzopyridooxathiazepine (BZN), a potent tubulin polymerization inhibitor, was investigated by liquid chromatography-UV detection (LC-UV). First, easy and quick LC-UV strategies have been optimized and validated to judge the pharmacokinetic profile of BZN utilizing rat liver microsomes or hepatocytes main cultures suspensions. Regardless of the medium investigated, baseline decision between the interior commonplace and BZN was achieved in a run time lower than 15min utilizing a Symmetry ODS column (150mm×4.6mm i.d., 5μm) and a cell part consisting of acetonitrile/water/formic acid 60:40:0.1 (v/v/v). Linearity was assessed within the 0.1-50μM and within the 0.05-5μM focus ranges, respectively, in microsomal and hepatocyte matrix.

Based on the novel technique based mostly on the construct of the accuracy profile, whole error of the developed strategies was included inside the ±10% limits of acceptance. Then, from incubation of BZN with each liver microsomes and or hepatocytes, structural informations on part I and part II metabolites have been acquired utilizing liquid chromatography coupled to electrospray orbitrap mass spectrometer (LC-MS). Mass spectrum, double bond equal and elemental composition have been helpful knowledge to entry to the chemical construction of every metabolite.

In microsomal suspension, 4 predominant metabolites have been noticed together with monohydroxylation and dihydroxylation of the benzopyridooxathiazepine core, demethylation of the methoxyphenyl moiety, in addition to their mixtures. The part II metabolites detected in hepatocytes suspension have been the glucuronide adducts of each demethylated BZN and mono-oxygenated BZN. Primarily based on the structural elucidation of the metabolites detected, we proposed an in vitro metabolic pathway of BZN, a brand new tubulin polymerization inhibitor.

In vitro metabolism of BIIB021, an inhibitor of warmth shock protein 90, in liver microsomes and hepatocytes of rats, canines, and people and recombinant human cytochrome P450 isoforms.

Inhibition of warmth shock protein 90 (HSP90) ends in the degradation of oncoproteins that drive malignant development and induce cell loss of life, thus making HSP90 a possible goal of most cancers remedy. 6-Chloro-9-(4-methoxy-3, 5-dimethyl-pyridin-2-ylmethyl)-9H-purin-2-ylamine (BIIB021), an artificial HSP90 inhibitor, exhibited promising antitumor exercise in preclinical fashions. It’s at present in part II medical trials for the oral remedy of breast most cancers. The target of this examine was to acquire each quantitative and qualitative metabolic profiles of [(14)C]BIIB021 in rat, canine, and human liver microsomes and hepatocytes to supply assist for in vivo security and medical research.

The metabolites of [(14)C]BIIB021 have been recognized utilizing liquid chromatography-tandem mass spectrometry coupled with radiometric detection. BIIB021 was extensively metabolized in each liver microsomes and hepatocytes. The foremost oxidative metabolic pathways recognized for all species have been attributable to hydroxylation (M7) and O-demethylation (M2) of the methoxy-dimethylpyridine moiety. The vast majority of M7 in canine hepatocytes was additional conjugated to type the glucuronide (M4). Oxidative dechlorination (M6), monooxygenation (M10), and oxidative N-dealkylation of the methoxy-dimethylpyridine moiety (M11 and M12) have been noticed because the minor metabolic pathways in hepatocytes of all three species. A glutathione conjugate (M18) was additionally recognized in all species.

In vitro pharmacokinetic profile of a benzopyridooxathiazepine derivative using rat microsomes and hepatocytes: identification of phases I and II metabolites.

Its formation was catalyzed, partially, by soluble glutathione transferase by way of direct displacement of the chlorine on the amino-chloropurine moiety. Subsequent minor secondary metabolites M13, M14, M15, and M17 have been noticed in human, canine, and rat hepatocytes. Outcomes from incubations of BIIB021 with human recombinant cytochrome P450 (P450) isoforms and a P450 antibody inhibition examine in human liver microsomes urged that the formation of M7 is especially catalyzed by CYP2C19 and CYP3A4, whereas the formation of minor metabolite M2 in human liver microsomes most likely may very well be attributed to CYP3A4.

In vitro metabolism of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rat, monkey, and human liver microsomes and freshly remoted hepatocytes.

The in vitro metabolism of rivoglitazone, (RS)-5-{4-[(6-methoxy-1-methyl-1H-benzimidazol-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione monohydrochloride, a novel thiazolidinedione (TZD) peroxisome proliferator-activated receptor γ selective agonist, was studied in liver microsomes and freshly remoted hepatocytes of rat, monkey, and human in addition to cDNA-expressed human cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT) enzymes. Fourteen metabolites have been detected, and these constructions have been elucidated by liquid chromatography-tandem mass spectrometry.

5 preliminary metabolic pathways of rivoglitazone consisting of 4 oxidation pathways and one N-glucuronidation pathway have been predicted in correspondence with these proposed for in vivo research utilizing rats and monkeys. In metabolization utilizing liver microsomes, the TZD ring-opened mercapto amide (M22) and TZD ring-opened mercapto carboxylic acid (M23) have been recognized as the first metabolite of the TZD ring-opening pathway and its sequential metabolite, which haven’t been detected beforehand from in vivo research. Mixture with S-adenosyl-L-methionine was helpful to acquire the sequential S-methylated metabolites from the oxidative metabolites.

Serum, Rat, Sprague Dawley, Female

MBS638869-25mL 25mL
EUR 710

Serum, Rat, Sprague Dawley, Female

MBS638869-50mL 50mL
EUR 1035

Serum, Rat, Sprague Dawley, Female

MBS638869-5x50mL 5x50mL
EUR 4430

*Rat Renin Substrate Plasma Female

IRTRENSPF10ML each
EUR 4211
Description: *Rat Renin Substrate Plasma Female

*Rat Renin Substrate Plasma Female

IRTRENSPF1ML each
EUR 528
Description: *Rat Renin Substrate Plasma Female

Kinesis Female Luer - Female union 1/8 - EACH

CHR4263 EACH
EUR 13.5

Kinesis Adapter 10.32 Female to 1/4-28 Female - EACH

CHR4259 EACH
EUR 43.2

Kinesis Adapter Female luer to Female 10-32 ETFE - EACH

CHR4267 EACH
EUR 8.1

Rat Long Evans Genomic DNA, Female

GRL-180F 0.1mg
EUR 177

Rat Sprague Dawley Genomic DNA, Female

GRS-180F 0.1mg
EUR 177

Kinesis Luer Adapter Female x 1/4-28 Female Tefzel - EACH

CHR4353 EACH
EUR 13.5

Kinesis Adapter Female luer to 10-32 Female PEEK - EACH

CHR4315 EACH
EUR 33.75

Kinesis Adapter Luer Female to M6 Female; Black PEEK - EACH

CHR4317 EACH
EUR 25.65

Kinesis Adapter 5/16-24 Female to 1/2-20 Female PEEK - EACH

CHR5095 EACH
EUR 87.75

Kinesis Adaptor 5/16-24 Female To 1/4-28 Female; PEEK - EACH

CHR3793 EACH
EUR 31.05

Kinesis Adaptor Body 1/2-20 Female x 1/4-28 Female - EACH

CHR5105 EACH
EUR 62.1

Urine, Human, Female

MBS641014-50mL 50mL
EUR 485

Urine, Human, Female

MBS641014-5x50mL 5x50mL
EUR 1960

Rat Renin Substrate Plasma, Female, Sodium EDTA

MBS135600-10mL 10mL
EUR 5230

Rat Renin Substrate Plasma, Female, Sodium EDTA

MBS135600-1mL 1mL
EUR 750

Female FPLC Connector

FFC-1 1
EUR 43.86

Dog Genomic DNA, Female

GD-150F 0.1mg
EUR 177

Human Genomic DNA, female

GH-180F 0.1mg
EUR 177

Sheep Genomic DNA, Female

GS-190F 0.1mg
EUR 177

Rabbit Genomic DNA, Female

GR-170F 0.1mg
EUR 177

Bovine Genomic DNA , Female

GB-110F 0.1mg
EUR 177

Female Nut BSPP R/H

GAS1086 EACH
EUR 23.14

Chicken Genomic DNA, Female

GC-120F 0.1mg
EUR 177

Porcine Genomic DNA, Female

GP-160F 0.1mg
EUR 177

Fecal Matter - Normal - Female

MBS170591-10Samples 10Samples
EUR 2360

Fecal Matter - Normal - Female

MBS170591-1Sample 1Sample
EUR 425

Fecal Matter - Normal - Female

MBS170591-5x10Samples 5x10Samples
EUR 10405

C-FLEX TUBING, 3'- 1/4" ID, WITH FEMALE MPC CONNECTOR TO FEMALE LUER W/CAP

91-700-04 1/pk
EUR 82.8
Description: Flexible Containers; Bioprocess Bags and Parts

Serum, Monkey, Cynomolgus, Female

MBS638816-10mL 10mL
EUR 440

Serum, Monkey, Cynomolgus, Female

MBS638816-25mL 25mL
EUR 870

Serum, Monkey, Cynomolgus, Female

MBS638816-50mL 50mL
EUR 1350

Serum, Monkey, Cynomolgus, Female

MBS638816-5x50mL 5x50mL
EUR 5845

Control Genomic DNA - Dog Female

D1734999-G02 100 ug
EUR 196

Buccal Swab, Female Human Donor

MBS170497-1Sample 1Sample
EUR 260

Buccal Swab, Female Human Donor

MBS170497-5Samples 5Samples
EUR 675

Buccal Swab, Female Human Donor

MBS170497-5x5Samples 5x5Samples
EUR 2820

Frog Xenopus Genomic DNA. Female

GF-240F 0.1mg
EUR 177

Sweat, Single Human Female Donor

MBS170262-1Sample 1Sample
EUR 310

Sweat, Single Human Female Donor

MBS170262-5Samples 5Samples
EUR 1005

Sweat, Single Human Female Donor

MBS170262-5x5Samples 5x5Samples
EUR 4310

Rat Cytochrome P450 2C12, female-specific (CYP2C12) ELISA Kit

abx508262-96tests 96 tests
EUR 687.5

Control Genomic DNA - Human Female

D1234999-G02 100 ug
EUR 196

Control Genomic DNA - Mouse Female

D1334999-G02 100 ug
EUR 196

Control Genomic DNA - Horse Female

D1O34999-G02 100 ug
EUR 196

Kinesis Female Luer Fittings - PK2

CHR1247 PK2
EUR 8.1

Saliva, Single Female Human Donor

MBS170210-1Sample 1Sample
EUR 210

Saliva, Single Female Human Donor

MBS170210-5Samples 5Samples
EUR 470

Saliva, Single Female Human Donor

MBS170210-5x5Samples 5x5Samples
EUR 1905

Normal Urine, Single Female Donor

MBS170218-100Samples 100Samples
EUR 5905

Normal Urine, Single Female Donor

MBS170218-10Samples 10Samples
EUR 820

Normal Urine, Single Female Donor

MBS170218-1Sample 1Sample
EUR 220

Normal Urine, Single Female Donor

MBS170218-5x100Samples 5x100Samples
EUR 26355

Vaginal Swabs, Female Human Donor

MBS170495-1Sample 1Sample
EUR 330

Vaginal Swabs, Female Human Donor

MBS170495-3Samples 3Samples
EUR 680

Vaginal Swabs, Female Human Donor

MBS170495-5x3Samples 5x3Samples
EUR 2855

Control Genomic DNA - Rabbit Female

D1834999-G02 100 ug
EUR 196

Control Genomic DNA - Bovine Female

D1B34999-G02 100 ug
EUR 196

Vaginal Fluid, Single Female Donor

MBS170232-01mL 0.1mL
EUR 680

Vaginal Fluid, Single Female Donor

MBS170232-025mL 0.25mL
EUR 995

Vaginal Fluid, Single Female Donor

MBS170232-10mL 10mL
EUR 6340

Vaginal Fluid, Single Female Donor

MBS170232-1mL 1mL
EUR 2125

Vaginal Fluid, Single Female Donor

MBS170232-5x10mL 5x10mL
EUR 28320

Recombinant Rat Meiosis arrest female protein 1 (Marf1) , partial

MBS1316123-INQUIRE INQUIRE Ask for price

Tissue, Control Genomic DNA, Rat Adult Normal, Female, BioGenomics

MBS654404-01mg 0.1mg
EUR 460

Tissue, Control Genomic DNA, Rat Adult Normal, Female, BioGenomics

MBS654404-5x01mg 5x0.1mg
EUR 1925

HUMAN, SERUM, FEMALE, UNFILTERED, UNIT

7323801 1UNIT
EUR 728.2

Control Genomic DNA - Porcine Female

D1934999-G02 100 ug
EUR 196

Control Genomic DNA - Chicken Female

D1C34999-G02 100 ug
EUR 196

Control Genomic DNA - Hamster Female

D1H34999-G02 100 ug
EUR 196

Hamster, Chinese, Genomic DNA, Female*

GA-170CF 0.05mg
EUR 177

Salmon, Atlantic Genomic DNA, Female

GFS-190F 0.05mg
EUR 177

Hamster, Armenian, Genomic DNA, Female

GA-170AF 0.1mg
EUR 177

RAT, WISTAR, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 100 ML

7368300-100ML 1ML
EUR 223.75

RAT, WISTAR, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 25 ML

7368300-25ML 1ML
EUR 89.06

RAT, WISTAR, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 500 ML

7368300-500ML 1ML
EUR 1053.9

RAT, WISTAR, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 50 ML

7368300-50ML 1ML
EUR 127.12

Mouse BALB/C Genomic DNA, Female

GMB-150F 0.1mg
EUR 177

Mouse ICR (CD1) Genomic DNA, Female

GMI-150F 0.1mg
EUR 177

Human Mammary Epithelial Cells, Female

ABC-TC3692 1 vial Ask for price
Description: Human Mammary Epithelial Cells, when grown in LIMam Medium, provide an ideal serum-free culture model for many areas of research. Common uses of HMEC include the stages of breast cancer development, three dimensional culture and carcinogen screening.Cell Features:HMEC are cryopreserved as tertiary cells, e.g. cells are isolated from human mammary tissue and expanded three times in culture vessels before being harvested for cryopreservation.HMEC are extensively tested for quality and optimal performance.Gentaur guarantees performance and quality.

Mouse C57BL/6J Genomic DNA, Female

GMC-150F 0.1mg
EUR 177

Female Nut BSPP L/H 6mm - EACH

GAS1092 EACH
EUR 17.26

FBS - Female Only Fetal Bovine Serum

FBS001-F each
EUR 581.4

Human Hepatocytes-Single Donor, Female

ABC-TC3647 1 vial Ask for price
Description: Gentaur's hepatocytes for suspension assays (HP1 Heps-s, single donor, female) provide an economic source of characterized human hepatocytes for use in short-term suspension assays to evaluate the metabolism of drug candidates. Gentaur's hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Female reproductive system tissue array

FRS801 each
EUR 306
Description: Female reproductive system tissue array, with stage and grade info, 80 cases/80 cores

Neurons (iPSC from Blood Cells; Female)

ASE-9321F 1 vial (1 x 10^6)
EUR 375.9
Description: 12 month

Age grouped female skin tissue array

SK244a each
EUR 270
Description: Age grouped female skin tissue array, 12 cases/24 cores, replacing SK244

Control Genomic DNA - Guinea Pig Female

D1G34999-G02 100 ug
EUR 196

Single Donor Human Female Rectal Swab

IRHUSRCTSWBFEM1 each
EUR 428
Description: Single Donor Human Female Rectal Swab

Kinesis Female Nut (Micro Fittings) - EACH

CHR4137 EACH
EUR 13.5

Single Donor Human Female Fecal Matter

IRHUFSMFEM1 each
EUR 382
Description: Single Donor Human Female Fecal Matter

Single Donor Human Female Fecal Matter

IRHUFSMFEM5 each
EUR 3566
Description: Single Donor Human Female Fecal Matter

Single Donor Human Female Fecal Matter

MBS8421276-INQUIRE INQUIRE Ask for price

RAT, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 100 ML

7347101-100ML 1ML
EUR 247.18

RAT, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 25 ML

7347101-25ML 1ML
EUR 96.38

RAT, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 500 ML

7347101-500ML 1ML
EUR 1163.71

RAT, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 50 ML

7347101-50ML 1ML
EUR 141.76

RAT, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 100 ML

7347104-100ML 1ML
EUR 247.18

RAT, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 25 ML

7347104-25ML 1ML
EUR 96.38

RAT, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 500 ML

7347104-500ML 1ML
EUR 1163.71

RAT, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 50 ML

7347104-50ML 1ML
EUR 141.76

Kinesis Luer Female - 1/8in Barb - EACH

CHR4593 EACH
EUR 2.7

Control Genomic DNA - Rhesus Monkey Female

D1534999-G02 100 ug
EUR 196

Hamster, Syrian Golden, Genomic DNA, Female

GA-170F 0.1mg
EUR 177

Single Donor Human Female Perianal Swabs

IRHUSPANSWBFEM1 each
EUR 763
Description: Single Donor Human Female Perianal Swabs

Single Donor Human Female Perianal Swabs

IRHUSPANSWBFEM5 each
EUR 3809
Description: Single Donor Human Female Perianal Swabs

Single Donor Human Female Perianal Swabs

MBS8421304-INQUIRE INQUIRE Ask for price

Kinesis Luer Female - 3/32in Barb - EACH

CHR4591 EACH
EUR 4.05

Kinesis Siltite Fingertight Female Nut - PK5

CHR1941 PK5
EUR 153.9

RAT, SPRAGUE DAWLEY, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 100 ML

7368000-100ML 1ML
EUR 204.72

RAT, SPRAGUE DAWLEY, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 25 ML

7368000-25ML 1ML
EUR 89.06

RAT, SPRAGUE DAWLEY, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 500 ML

7368000-500ML 1ML
EUR 821.11

RAT, SPRAGUE DAWLEY, CONTROL SERUM, NON DOMESTIC, FEMALE, UNFILTERED, 50 ML

7368000-50ML 1ML
EUR 127.12

RAT, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 100 ML

7347103-100ML 1ML
EUR 247.18

RAT, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 25 ML

7347103-25ML 1ML
EUR 96.38

RAT, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 500 ML

7347103-500ML 1ML
EUR 1163.71

RAT, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 50 ML

7347103-50ML 1ML
EUR 141.76

Recombinant Cricetulus migratorius Female protein

MBS1126780-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1130

Recombinant Cricetulus migratorius Female protein

MBS1126780-002mgEColi 0.02mg(E-Coli)
EUR 715

Recombinant Cricetulus migratorius Female protein

MBS1126780-002mgYeast 0.02mg(Yeast)
EUR 885

Recombinant Cricetulus migratorius Female protein

MBS1126780-01mgEColi 0.1mg(E-Coli)
EUR 860

Recombinant Cricetulus migratorius Female protein

MBS1126780-01mgYeast 0.1mg(Yeast)
EUR 1035

Kinesis Female Luer - M6 Tefzel Black - EACH

CHR4363 EACH
EUR 9.45

Single Donor Human Female Rectal Swab 1

MBS8421307-INQUIRE INQUIRE Ask for price

Control Genomic DNA - Cynomolgus Monkey Female

D1534999-Cy-G02 100 ug
EUR 196

RAT, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 100 ML

7347107-100ML 1ML
EUR 247.18

RAT, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 25 ML

7347107-25ML 1ML
EUR 96.38

RAT, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 500 ML

7347107-500ML 1ML
EUR 1163.71

RAT, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 50 ML

7347107-50ML 1ML
EUR 141.76

RAT, CONTROL PLASMA, NON DOMESTIC, K3 EDTA, DONOR, FEMALE, UNFILTERED, 100 ML

7347108-100ML 1ML
EUR 247.18

RAT, CONTROL PLASMA, NON DOMESTIC, K3 EDTA, DONOR, FEMALE, UNFILTERED, 25 ML

7347108-25ML 1ML
EUR 96.38

RAT, CONTROL PLASMA, NON DOMESTIC, K3 EDTA, DONOR, FEMALE, UNFILTERED, 500 ML

7347108-500ML 1ML
EUR 1163.71

RAT, CONTROL PLASMA, NON DOMESTIC, K3 EDTA, DONOR, FEMALE, UNFILTERED, 50 ML

7347108-50ML 1ML
EUR 141.76

RAT, CONTROL PLASMA, NON DOMESTIC, NA EDTA, DONOR, FEMALE, UNFILTERED, 100 ML

7347109-100ML 1ML
EUR 247.18

RAT, CONTROL PLASMA, NON DOMESTIC, NA EDTA, DONOR, FEMALE, UNFILTERED, 25 ML

7347109-25ML 1ML
EUR 96.38

RAT, CONTROL PLASMA, NON DOMESTIC, NA EDTA, DONOR, FEMALE, UNFILTERED, 500 ML

7347109-500ML 1ML
EUR 1163.71

RAT, CONTROL PLASMA, NON DOMESTIC, NA EDTA, DONOR, FEMALE, UNFILTERED, 50 ML

7347109-50ML 1ML
EUR 141.76

Female reproductive system tumor tissue array

FE951 each
EUR 354
Description: Female reproductive system tumor tissue array, including pathology grade, TNM and clinical stage (AJCC 8.0), 95 cases/95 cores (core size 1.5mm), Recent Year Collection

Kinesis 10-32 Female to Male Luer Nut - EACH

CHR4311 EACH
EUR 18.9

Kinesis Female Luer to MicroTight Body - EACH

CHR4323 EACH
EUR 85.05

RAT, CONTROL PLASMA, NON DOMESTIC, NA CITRATE, DONOR, FEMALE, UNFILTERED, 100 ML

7347106-100ML 1ML
EUR 247.18

RAT, CONTROL PLASMA, NON DOMESTIC, NA CITRATE, DONOR, FEMALE, UNFILTERED, 25 ML

7347106-25ML 1ML
EUR 96.38

RAT, CONTROL PLASMA, NON DOMESTIC, NA CITRATE, DONOR, FEMALE, UNFILTERED, 500 ML

7347106-500ML 1ML
EUR 1163.71

RAT, CONTROL PLASMA, NON DOMESTIC, NA CITRATE, DONOR, FEMALE, UNFILTERED, 50 ML

7347106-50ML 1ML
EUR 141.76

RAT, CONTROL PLASMA, NON DOMESTIC, LI HEPARIN, DONOR, FEMALE, UNFILTERED, 100 ML

7347110-100ML 1ML
EUR 247.18

RAT, CONTROL PLASMA, NON DOMESTIC, LI HEPARIN, DONOR, FEMALE, UNFILTERED, 25 ML

7347110-25ML 1ML
EUR 96.38

RAT, CONTROL PLASMA, NON DOMESTIC, LI HEPARIN, DONOR, FEMALE, UNFILTERED, 500 ML

7347110-500ML 1ML
EUR 1163.71

RAT, CONTROL PLASMA, NON DOMESTIC, LI HEPARIN, DONOR, FEMALE, UNFILTERED, 50 ML

7347110-50ML 1ML
EUR 141.76

RAT, CONTROL PLASMA, NON DOMESTIC, NA HEPARIN, DONOR, FEMALE, UNFILTERED, 100 ML

7347111-100ML 1ML
EUR 247.18

RAT, CONTROL PLASMA, NON DOMESTIC, NA HEPARIN, DONOR, FEMALE, UNFILTERED, 25 ML

7347111-25ML 1ML
EUR 96.38

RAT, CONTROL PLASMA, NON DOMESTIC, NA HEPARIN, DONOR, FEMALE, UNFILTERED, 500 ML

7347111-500ML 1ML
EUR 1163.71

RAT, CONTROL PLASMA, NON DOMESTIC, NA HEPARIN, DONOR, FEMALE, UNFILTERED, 50 ML

7347111-50ML 1ML
EUR 141.76

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 100 ML

7348301-100ML 1ML
EUR 231.07

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 25 ML

7348301-25ML 1ML
EUR 96.38

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 500 ML

7348301-500ML 1ML
EUR 1061.22

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ACD, DONOR, FEMALE, UNFILTERED, 50 ML

7348301-50ML 1ML
EUR 141.76

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 100 ML

7348304-100ML 1ML
EUR 231.07

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 25 ML

7348304-25ML 1ML
EUR 96.38

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 500 ML

7348304-500ML 1ML
EUR 1061.22

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, CPD, DONOR, FEMALE, UNFILTERED, 50 ML

7348304-50ML 1ML
EUR 141.76

Kinesis Adapter SS 10.32 Female to 1/4-28 Male - EACH

CHR2347 EACH
EUR 40.5

Serum - Plasma Derived Serum Units - Female Only

MBS173719-INQUIRE INQUIRE Ask for price

Human Hepatocytes-Single Donor, Female; Inducible

ABC-TC3648 1 vial Ask for price
Description: Gentaur's inducible hepatocytes (HP1 Heps-i, single donor, female) can be plated and used in long-term drug induction studies or metabolic studies where long-term incubations are required. Gentaur's cryopreserved primary human hepatocytes are a functional, convenient and economical solution for your drug testing and basic research needs. Each lot is tested for plating and provided with extensive characterization of metabolic functionality to ensure that you receive an ideal model for drug testing, drug development or other metabolic studies. Gentaur's human hepatocytes eliminate the need and expense of obtaining liver tissue, and conducting multiple cell isolations; and Gentaur also provides hepatocyte-tested culture reagents and instructions necessary for thawing and culturing your hepatocytes.Cell Features:Suitable for induction assays or metabolic characterization assays in plated or suspension cultures. Plated cultures are excellent for long-term intrinsic clearance assays.Hepatocytes are cryopreserved ONCE immediately after isolation and purification.Characterization of viability and enzyme activity, including fold-induction of CYP1A2, CYP2B6 and CYP3A4 for HP1 Heps-i.Gentaur guarantees performance and quality.Donor demographics and medical information are available.

Kinesis Adapter PEEK 10.32 Female to 1/4-28 Male - EACH

CHR4333 EACH
EUR 43.2

Normal female dog multiple organs tissue array

DGF281 each
EUR 306
Description: Normal female dog multiple organs tissue array, 28 organs/ 28cores

Astrocytes Mature (iPSC from Blood Cells; Female)

ASE-9322MF 1 vial (1 x 10^6)
EUR 546
Description: 12 month

Human Niemann Pick Type C (Female) iPS Cells

CR1013-500 1 vial
EUR 1050
Description: Cryopreserved vial of induced pluripotent stem cells from a single female donor with Niemann-Pick disease type C (500,000 cells)

Adapter X2 M30x1.5 female to NPT 3/4" male

8890083 PK2
EUR 239.8

Kinesis Luer Assembly M6 Female to Male - EACH

CHR4313 EACH
EUR 27

V-Neck Polycotton Lab Coat - Female - 100cm/40in - Medium - EACH

SAF0078 EACH
EUR 68.85

Kinesis Female Luer Fitting System - 1/8 - EACH

CHR4545 EACH
EUR 8.1

Kinesis Female Luer Fitting System - 1/16 - EACH

CHR4553 EACH
EUR 8.1

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 100 ML

7348303-100ML 1ML
EUR 231.07

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 25 ML

7348303-25ML 1ML
EUR 96.38

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 500 ML

7348303-500ML 1ML
EUR 1061.22

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, ALSEVERS, DONOR, FEMALE, UNFILTERED, 50 ML

7348303-50ML 1ML
EUR 141.76

Kinesis Female Nut 5/16-24 PEEK Black - EACH

CHR4139 EACH
EUR 13.5

Kinesis Female Luer to 10-32 Male PEEK - EACH

CHR4419 EACH
EUR 52.65

Dopaminergic Neurons (iPSC from Blood Cells; Female)

ASE-9323F 1 vial
EUR 448.8
Description: 12 month

Neural Stem Cells (iPSC from Blood Cells; Female)

ASE-9234F 1 vial (1 x 10^6)
EUR 497.4
Description: 12 month

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 100 ML

7348307-100ML 1ML
EUR 231.07

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 25 ML

7348307-25ML 1ML
EUR 96.38

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 500 ML

7348307-500ML 1ML
EUR 1061.22

RAT, WISTAR, CONTROL PLASMA, NON DOMESTIC, K2 EDTA, DONOR, FEMALE, UNFILTERED, 50 ML

7348307-50ML 1ML
EUR 141.76

N-Glucuronide and sequential TZD ring-opened metabolites have been additionally present in liver microsomes within the presence of UDP-glucuronic acid. The O-demethyl-O-sulfate (M11), which is the main in vivo metabolite in rats and monkeys, was detected in all species of hepatocytes. As well as, a TZD ring-opened S-cysteine conjugate (M15) was detected in human hepatocytes. From these outcomes, the in vivo metabolic pathways in people have been predicted to be the 4 oxidation and one N-glucuronidation pathways. The 4 oxidative metabolites have been fashioned by a number of human P450 enzymes, and N-glucuronide was fashioned by UGT1A3 and UGT2B7.

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