Within the current examine, the in vitro metabolic habits of a benzopyridooxathiazepine (BZN), a potent tubulin polymerization inhibitor, was investigated by liquid chromatography-UV detection (LC-UV). First, easy and quick LC-UV strategies have been optimized and validated to judge the pharmacokinetic profile of BZN utilizing rat liver microsomes or hepatocytes main cultures suspensions. Regardless of the medium investigated, baseline decision between the interior commonplace and BZN was achieved in a run time lower than 15min utilizing a Symmetry ODS column (150mm×4.6mm i.d., 5μm) and a cell part consisting of acetonitrile/water/formic acid 60:40:0.1 (v/v/v). Linearity was assessed within the 0.1-50μM and within the 0.05-5μM focus ranges, respectively, in microsomal and hepatocyte matrix.
Based on the novel technique based mostly on the construct of the accuracy profile, whole error of the developed strategies was included inside the ±10% limits of acceptance. Then, from incubation of BZN with each liver microsomes and or hepatocytes, structural informations on part I and part II metabolites have been acquired utilizing liquid chromatography coupled to electrospray orbitrap mass spectrometer (LC-MS). Mass spectrum, double bond equal and elemental composition have been helpful knowledge to entry to the chemical construction of every metabolite.
In microsomal suspension, 4 predominant metabolites have been noticed together with monohydroxylation and dihydroxylation of the benzopyridooxathiazepine core, demethylation of the methoxyphenyl moiety, in addition to their mixtures. The part II metabolites detected in hepatocytes suspension have been the glucuronide adducts of each demethylated BZN and mono-oxygenated BZN. Primarily based on the structural elucidation of the metabolites detected, we proposed an in vitro metabolic pathway of BZN, a brand new tubulin polymerization inhibitor.
In vitro metabolism of BIIB021, an inhibitor of warmth shock protein 90, in liver microsomes and hepatocytes of rats, canines, and people and recombinant human cytochrome P450 isoforms.
Inhibition of warmth shock protein 90 (HSP90) ends in the degradation of oncoproteins that drive malignant development and induce cell loss of life, thus making HSP90 a possible goal of most cancers remedy. 6-Chloro-9-(4-methoxy-3, 5-dimethyl-pyridin-2-ylmethyl)-9H-purin-2-ylamine (BIIB021), an artificial HSP90 inhibitor, exhibited promising antitumor exercise in preclinical fashions. It’s at present in part II medical trials for the oral remedy of breast most cancers. The target of this examine was to acquire each quantitative and qualitative metabolic profiles of [(14)C]BIIB021 in rat, canine, and human liver microsomes and hepatocytes to supply assist for in vivo security and medical research.
The metabolites of [(14)C]BIIB021 have been recognized utilizing liquid chromatography-tandem mass spectrometry coupled with radiometric detection. BIIB021 was extensively metabolized in each liver microsomes and hepatocytes. The foremost oxidative metabolic pathways recognized for all species have been attributable to hydroxylation (M7) and O-demethylation (M2) of the methoxy-dimethylpyridine moiety. The vast majority of M7 in canine hepatocytes was additional conjugated to type the glucuronide (M4). Oxidative dechlorination (M6), monooxygenation (M10), and oxidative N-dealkylation of the methoxy-dimethylpyridine moiety (M11 and M12) have been noticed because the minor metabolic pathways in hepatocytes of all three species. A glutathione conjugate (M18) was additionally recognized in all species.

Its formation was catalyzed, partially, by soluble glutathione transferase by way of direct displacement of the chlorine on the amino-chloropurine moiety. Subsequent minor secondary metabolites M13, M14, M15, and M17 have been noticed in human, canine, and rat hepatocytes. Outcomes from incubations of BIIB021 with human recombinant cytochrome P450 (P450) isoforms and a P450 antibody inhibition examine in human liver microsomes urged that the formation of M7 is especially catalyzed by CYP2C19 and CYP3A4, whereas the formation of minor metabolite M2 in human liver microsomes most likely may very well be attributed to CYP3A4.
In vitro metabolism of rivoglitazone, a novel peroxisome proliferator-activated receptor γ agonist, in rat, monkey, and human liver microsomes and freshly remoted hepatocytes.
The in vitro metabolism of rivoglitazone, (RS)-5-{4-[(6-methoxy-1-methyl-1H-benzimidazol-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione monohydrochloride, a novel thiazolidinedione (TZD) peroxisome proliferator-activated receptor γ selective agonist, was studied in liver microsomes and freshly remoted hepatocytes of rat, monkey, and human in addition to cDNA-expressed human cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT) enzymes. Fourteen metabolites have been detected, and these constructions have been elucidated by liquid chromatography-tandem mass spectrometry.
5 preliminary metabolic pathways of rivoglitazone consisting of 4 oxidation pathways and one N-glucuronidation pathway have been predicted in correspondence with these proposed for in vivo research utilizing rats and monkeys. In metabolization utilizing liver microsomes, the TZD ring-opened mercapto amide (M22) and TZD ring-opened mercapto carboxylic acid (M23) have been recognized as the first metabolite of the TZD ring-opening pathway and its sequential metabolite, which haven’t been detected beforehand from in vivo research. Mixture with S-adenosyl-L-methionine was helpful to acquire the sequential S-methylated metabolites from the oxidative metabolites.
Female FPLC Connector |
FFC-1 |
ABTBeads |
1/pk |
EUR 93.6 |
C-FLEX TUBING, 3'- 1/4" ID, WITH FEMALE MPC CONNECTOR TO FEMALE LUER W/CAP |
91-700-04 |
CORNING |
1/pk |
EUR 82.8 |
Description: Flexible Containers; Bioprocess Bags and Parts |
Control Genomic DNA - Dog Female |
D1734999-G02 |
Biochain |
100 ug |
EUR 170 |
Control Genomic DNA - Mouse Female |
D1334999-G02 |
Biochain |
100 ug |
EUR 170 |
Control Genomic DNA - Horse Female |
D1O34999-G02 |
Biochain |
100 ug |
EUR 170 |
Control Genomic DNA - Human Female |
D1234999-G02 |
Biochain |
100 ug |
EUR 170 |
Control Genomic DNA - Rabbit Female |
D1834999-G02 |
Biochain |
100 ug |
EUR 170 |
Control Genomic DNA - Bovine Female |
D1B34999-G02 |
Biochain |
100 ug |
EUR 170 |
Control Genomic DNA - Porcine Female |
D1934999-G02 |
Biochain |
100 ug |
EUR 170 |
Control Genomic DNA - Chicken Female |
D1C34999-G02 |
Biochain |
100 ug |
EUR 170 |
Control Genomic DNA - Hamster Female |
D1H34999-G02 |
Biochain |
100 ug |
EUR 170 |
Female reproductive system tissue array |
FRS801 |
TissueArray |
each |
EUR 306 |
Description: Female reproductive system tissue array, with stage and grade info, 80 cases/80 cores |
Neurons (iPSC from Blood Cells; Female) |
ASE-9321F |
Applied StemCell |
1 vial (1 x 10^6) |
EUR 375.9 |
Description: 12 month |
Age grouped female skin tissue array |
SK244a |
TissueArray |
each |
EUR 270 |
Description: Age grouped female skin tissue array, 12 cases/24 cores, replacing SK244 |
Control Genomic DNA - Guinea Pig Female |
D1G34999-G02 |
Biochain |
100 ug |
EUR 170 |
Control Genomic DNA - Rhesus Monkey Female |
D1534999-G02 |
Biochain |
100 ug |
EUR 170 |
Control Genomic DNA - Cynomolgus Monkey Female |
D1534999-Cy-G02 |
Biochain |
100 ug |
EUR 170 |
Female reproductive system tumor tissue array |
FE951 |
TissueArray |
each |
EUR 354 |
Description: Female reproductive system tumor tissue array, including pathology grade, TNM and clinical stage (AJCC 8.0), 95 cases/95 cores (core size 1.5mm), Recent Year Collection |
Astrocytes Mature (iPSC from Blood Cells; Female) |
ASE-9322MF |
Applied StemCell |
1 vial (1 x 10^6) |
EUR 546 |
Description: 12 month |
Normal female dog multiple organs tissue array |
DGF281 |
TissueArray |
each |
EUR 306 |
Description: Normal female dog multiple organs tissue array, 28 organs/ 28cores |
Neural Stem Cells (iPSC from Blood Cells; Female) |
ASE-9234F |
Applied StemCell |
1 vial (1 x 10^6) |
EUR 497.4 |
Description: 12 month |
Dopaminergic Neurons (iPSC from Blood Cells; Female) |
ASE-9323F |
Applied StemCell |
1 vial |
EUR 448.8 |
Description: 12 month |
Astrocytes Precursors (iPSC from Blood Cells; Female) |
ASE-9322PF |
Applied StemCell |
1 vial (1 x 10^6) |
EUR 448.8 |
Description: 12 month |
Neurons Starter Kit (iPSC from Blood Cells; Female) |
ASE-9321KF |
Applied StemCell |
1 Kit |
EUR 473.1 |
Description: 12 month |
Multiplex ELISA Kit For Human Female Hormone - (8-plex) |
MEK1022 |
BosterBio |
1 kit |
EUR 1696.8 |
Dopaminergic Neurons Starter Kit (iPSC from Blood Cells; Female) |
ASE-9323KF |
Applied StemCell |
1 vial |
EUR 546 |
Description: 12 month |
Astrocytes Precursors Starter Kit (iPSC from Blood Cells; Female) |
ASE-9322PKF |
Applied StemCell |
1 Kit |
EUR 497.4 |
Description: 12 month |
Monkey Capuchin (Cebus) control (non-immunized) serum, Male and Female |
NMCB-1 |
Alpha Diagnostics |
0.5 ml |
EUR 196.8 |
CELLSTACK,FILLING ACCESSORY,3/8 IN C-FLEX,FEMALE MPC,S,1/4 |
11902 |
CORNING |
1/pk |
EUR 337.2 |
Description: Stackable Cell Culture; Closed Systems Cell Culture Chambers |
C-FLEX TUBING, 3'- 1/4" ID, WITH MALE LUER WITH CAP TO FEMALE LUER |
91-700-00 |
CORNING |
1/pk |
EUR 79.2 |
Description: Flexible Containers; Bioprocess Bags and Parts |
Frozen Tissue Array - Dog Female Adult Normal Tissue, Multi-tissue I |
T6734700-G02-1 |
Biochain |
1 slide |
EUR 239 |
Frozen Tissue Array - Dog Female Adult Normal Tissue, Multi-tissue I |
T6734700-G02-5 |
Biochain |
5 slides |
EUR 883 |
Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I |
T6834700-G02-1 |
Biochain |
1 slide |
EUR 239 |
Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I |
T6834700-G02-5 |
Biochain |
5 slides |
EUR 883 |
Option quick disconnect kit, includes 2 male/female attachments & silicone tubing |
V0020-QD |
Benchmark Scientific |
1 PC |
EUR 144.9 |
HeLa Cell Slide (Human (31 yrs, Female) cervix epithelioid carcinoma) (5 slides/pk) |
HCLS-17001 |
Alpha Diagnostics |
1 pk |
EUR 300 |
A-431 Cell Slide (Human (85 yrs, Female) skin epidermoid carcinoma) (5 slides/pk) |
HCLS-17002 |
Alpha Diagnostics |
1 pk |
EUR 300 |
Monkey Marmoset (Callithrix jacchus) control (non-immunized) serum, Male and Female |
NMMS-1 |
Alpha Diagnostics |
0.5 ml |
EUR 270 |
CELLSTACK,FILLING ACC,33MM CAP,MPC FEMALE QK CON,W/DUSTCVR,3/8"ID,S,IND,1/4 |
3329 |
CORNING |
1/pk |
EUR 337.2 |
Description: Stackable Cell Culture; CellSTACK |
Option quick disconnect kit, includes 2 male/female attachments and silicone tubing |
BCM1550 |
Bio Basic |
1 pcs, 1 UNIT |
EUR 244.87 |
|
Monkey African Green (Chlorocebus) control (non-immunized) serum, Male and Female Available |
NMAG-1 |
Alpha Diagnostics |
1 ml |
EUR 169.2 |
L1210 Cell Slide (DBA subline 212 Mouse (8 months, Female) lymphocytic leukemia) (5 slides/pk) |
MCLS-17204 |
Alpha Diagnostics |
1 pk |
EUR 300 |
MCF7 Cell Slide (Human (69 yrs, Female) mammary gland, breast, epithelial adenocarcinoma) (5 slides/pk) |
HCLS-17012 |
Alpha Diagnostics |
1 pk |
EUR 300 |
K-562 Cell Slide (Human (53yrs, Female) bone marrow, chronic myelogenous leukemia (CML)) (5 slides/pk) |
HCLS-17004 |
Alpha Diagnostics |
1 pk |
EUR 300 |
Corning 33mm Filling Cap with a Female MPC with a 1/4inch (6.4mm) ID Coupling and a Male MPC End Cap |
3328 |
Scientific Laboratory Supplies |
PK4 |
EUR 333.6 |
C-FLEX TUBING, 2'-1/4" ID, WITH FEMALE MPC CONNECTOR WITH 1/4" BARB WITH PINCH CLAMP AND FILLING BELL |
91-700-12 |
CORNING |
1/pk |
EUR 231.6 |
Description: Flexible Containers; Bioprocess Bags and Parts |
Corning 33mm Filling Cap 1/8inch ID Tubing and a Female Luer 1/8inch Hose Barb a Male Luer Lock Plug |
3282 |
Scientific Laboratory Supplies |
PK5 |
EUR 267.6 |
cDNA - Liver Cirrhosis: Liver |
C1236149Lcs |
Biochain |
40 reactions |
EUR 729 |
Rat Liver Tissue Lysate |
LYSATE0003 |
BosterBio |
200ug |
EUR 180 |
Description: This cell lysate is prepared from rat liver tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C. |
Liver Liver Cirrhosis Lysate |
XBL-10358 |
ProSci |
0.1 mg |
EUR 796.2 |
Description: Human liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human liver tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
HL-60 Cell Slide (Human (36yrs, Female) peripheral blood promyeloblast, acute promyelocytic leukemia) (5 slides/pk) |
HCLS-17009 |
Alpha Diagnostics |
1 pk |
EUR 300 |
Total RNA - Liver Cirrhosis: Liver |
R1236149Lcs-50 |
Biochain |
50 ug |
EUR 421.2 |
Rat Liver PrimaCell: Hepatocytes |
2-82595 |
CHI Scientific |
1 Kit |
Ask for price |
Rat Ferritin (Liver) Antibody |
11901-05011 |
AssayPro |
150 ug |
EUR 260.4 |
Total Protein - Liver Cirrhosis: Liver |
P1236149Lcs |
Biochain |
1 mg |
EUR 471 |
Liver Membrane Liver Cirrhosis Lysate |
XBL-10671 |
ProSci |
0.1 mg |
EUR 752.1 |
Description: Human liver tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human liver tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated liver tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated liver tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal. |
Membrane Protein - Liver Cirrhosis: Liver |
P3236149Lcs |
Biochain |
0.1 mg |
EUR 410 |
Rat Liver glycogen ELISA kit |
E02H0052-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Rat Liver glycogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Liver glycogen ELISA kit |
E02H0052-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Rat Liver glycogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Liver glycogen ELISA kit |
E02H0052-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Rat Liver glycogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Liver cancer and liver tissue array |
BC03116a |
TissueArray |
each |
EUR 306 |
Description: Liver cancer and liver tissue array, including pathology grade, TNM and clinical stage, 70 cases/70 cores, replacing BC03116 |
Liver tumor with liver tissue array |
T032d |
TissueArray |
each |
EUR 48 |
Description: Liver tumor with liver tissue array, including pathology grade, TNM and clinical stage, 12 cases/24 cores, replacing T032c |
Liver cancer with liver tissue array |
LV1021a |
TissueArray |
each |
EUR 204 |
Description: Liver cancer with liver tissue array, including pathology grade, TNM and clinical stage, 102 cases/102 cores, replacing LV1021 |
Liver cancer with liver tissue array |
LV243 |
TissueArray |
each |
EUR 66 |
Description: Liver cancer with liver tissue array, including pathology grade, TNM and clinical stage, 12 cases/24 cores |
Liver cancer with liver tissue array |
LV722 |
TissueArray |
each |
EUR 306 |
Description: Liver cancer with liver tissue array, including pathology grade, TNM and clinical stage, 24 cases/72 cores, replacing LV721 |
Liver cancer with liver tissue array |
LV803b |
TissueArray |
each |
EUR 270 |
Description: Liver cancer with liver tissue array, including pathology grade, TNM and clinical stage, 54 cases/72 cores, replacing LV803a |
cDNA - Rat Normal Tissue: Liver |
C1434149 |
Biochain |
40 reactions |
EUR 385 |
Paraffin Tissue Section - Liver Cirrhosis: Liver |
T2236149Lcs |
Biochain |
5 slides |
EUR 238 |
Total RNA - Human Adult Normal Tissue: Peripheral Blood Leukocyte, from 4 different donors, 2 male and 2 female. 1 ug/ul concentration |
R1234148-10-P04 |
Biochain |
10x10 µg |
EUR 2199 |
Liver cancer and normal liver tissue array |
LV483a |
TissueArray |
each |
EUR 198 |
Description: Liver cancer and normal liver tissue array, including hepatocellular carcinoma,cholangiocellular carcinoma and normal tissues pathology grade, TNM and clinical stage (AJCC 7th edition), 48 cases/48 cores (core size 1.5mm), replacing LV483 |
Liver cancer with matched liver tissue array |
LV241b |
TissueArray |
each |
EUR 66 |
Description: Liver cancer with matched liver tissue array, including pathology grade, TNM and clinical stage, 6 cases/24 cores, replacing LV241a |
Multiple liver disease with liver tissue array |
LV601 |
TissueArray |
each |
EUR 306 |
Description: Multiple liver disease with liver tissue array, including pathology grade, TNM and clinical stage (reference AJCC 8th version), 46 cases/60 cores |
Liver Lysate |
1464 |
ProSci |
0.1 mg |
EUR 229.2 |
Description: Liver tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT. |
Liver Lysate |
21-105 |
ProSci |
0.1 mg |
EUR 342.6 |
Description: Bovine liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The bovine liver tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Liver Lysate |
21-406 |
ProSci |
0.1 mg |
EUR 342.6 |
Description: Porcine liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The porcine liver tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Liver Lysate |
21-419 |
ProSci |
0.1 mg |
EUR 342.6 |
Description: Rabbit liver tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The rabbit liver tissue total protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the liver tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The liver tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot. |
Liver cancer |
BC03117 |
TissueArray |
each |
EUR 306 |
Description: Liver cancer, liver cirrhosis tissue array with normal tissue as control, including TNM, clinical stage, pathology grade and history of hepatitis, 70 cases/ 80 cores, replaced by BC03117a |
Liver tissue |
LV805b |
TissueArray |
each |
EUR 270 |
Description: Liver tissue, hepatitis and cirrhosis tissue array, 80 cases/80 cores, replacing LV805a |
Rat Collectin Liver 1 ELISA kit |
E02C0405-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Rat Collectin Liver 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Collectin Liver 1 ELISA kit |
E02C0405-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Rat Collectin Liver 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Collectin Liver 1 ELISA kit |
E02C0405-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Rat Collectin Liver 1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Total RNA - Rat Normal Tissue: Liver |
R1434149-50 |
Biochain |
50 ug |
EUR 130 |
Rat Liver specific lipootein ELISA kit |
E02L0280-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A sandwich ELISA for quantitative measurement of Rat Liver specific lipootein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Liver specific lipootein ELISA kit |
E02L0280-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A sandwich ELISA for quantitative measurement of Rat Liver specific lipootein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Liver specific lipootein ELISA kit |
E02L0280-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A sandwich ELISA for quantitative measurement of Rat Liver specific lipootein in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat FibrOut 2, for cartilage, liver |
4-20529 |
CHI Scientific |
1 ml |
Ask for price |
Rat FibrOut 2, for cartilage, liver |
4-20530 |
CHI Scientific |
5 x 1 ml |
Ask for price |
Rat liver ferritin purified, ELISA grade |
FERT21-R-50 |
Alpha Diagnostics |
50 ug |
EUR 489.6 |
Genomic DNA - Rat Normal Tissue: Liver |
D1434149 |
Biochain |
100 ug |
EUR 286 |
Hepatitis B liver cancer and liver tissue array |
LV1401 |
TissueArray |
each |
EUR 474 |
Description: Hepatitis B liver cancer and liver tissue array, including pathology grade, TNM, clinical stage and HBV data, 99 cases/140 cores |
High density liver cancer with liver tissue array |
LV208 |
TissueArray |
each |
EUR 546 |
Description: High density liver cancer with liver tissue array, including pathology grade, TNM and clinical stage., 69 cases/207 cores |
High density liver cancer with liver tissue array |
LV2091 |
TissueArray |
each |
EUR 474 |
Description: High density liver cancer with liver tissue array, including pathology grade, TNM and clinical stage, 208 cases/208 cores |
Rat Phosphofructokinase, Liver (PFKL) Protein |
20-abx167625 |
Abbexa |
-
EUR 844.80
-
EUR 343.20
-
EUR 2598.00
-
EUR 994.80
-
EUR 594.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Liver cancer and normal adjacent liver tissue array |
LV801b |
TissueArray |
each |
EUR 306 |
Description: Liver cancer and normal adjacent liver tissue array, including pathology grade, TNM and clinical stage, 80 cases/80 cores (1.5mm), replacing LV801a |
Liver cancer with adjacent normal liver tissue array |
LV242a |
TissueArray |
each |
EUR 66 |
Description: Liver cancer with adjacent normal liver tissue array, including pathology grade, TNM and clinical stage (reference AJCC 7th version), 12 cases/24 cores, replacing LV242 |
Rat Liver X receptor alpha ELISA kit |
E02L0342-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Rat Liver X receptor alpha in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Liver X receptor alpha ELISA kit |
E02L0342-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Rat Liver X receptor alpha in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Liver X receptor alpha ELISA kit |
E02L0342-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Rat Liver X receptor alpha in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Liver Dissociation System 4 (Hepatocytes, rat), Rat |
4-20304 |
CHI Scientific |
ea |
Ask for price |
CK LIVER 1kg* |
43023-2 |
Pel-Freez |
1 kg |
EUR 288.11 |
Rat Liver OptiTDS: Tissue Dissociation System |
4-28322 |
CHI Scientific |
1 Kit |
Ask for price |
Rat Arginase 1 (Liver type) ELISA kit |
E02A0544-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Rat Arginase 1 (Liver type) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Arginase 1 (Liver type) ELISA kit |
E02A0544-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Rat Arginase 1 (Liver type) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Arginase 1 (Liver type) ELISA kit |
E02A0544-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Rat Arginase 1 (Liver type) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Genomic DNA - Liver Cirrhosis: Liver, from a single donor |
D1236149Lcs |
Biochain |
50 ug |
EUR 489 |
Rat Glycogen Phosphorylase, Liver ELISA kit |
E02P0171-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Rat Glycogen Phosphorylase, Liver in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Glycogen Phosphorylase, Liver ELISA kit |
E02P0171-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Rat Glycogen Phosphorylase, Liver in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat Glycogen Phosphorylase, Liver ELISA kit |
E02P0171-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Rat Glycogen Phosphorylase, Liver in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Different stages of liver cancer and liver tissue array |
LV808 |
TissueArray |
each |
EUR 306 |
Description: Different stages of liver cancer and liver tissue array, including pathology grade, TNM and clinical stage, 80 cases/80 cores |
Rat Liver Receptor Homolog 1 (LRH1) Protein |
20-abx650553 |
Abbexa |
-
EUR 844.80
-
EUR 343.20
-
EUR 2598.00
-
EUR 994.80
-
EUR 594.00
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Rat Phosphofructokinase, Liver (PFKL) CLIA Kit |
20-abx494255 |
Abbexa |
-
EUR 10282.80
-
EUR 5472.00
-
EUR 1262.40
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Chang Liver (HeLa) |
C0050007 |
Addexbio |
One Frozen vial |
EUR 651.6 |
cDNA - Lupus: Liver |
C1236149Lup |
Biochain |
40 reactions |
EUR 737 |
Human Liver CAFs |
CAF113 |
Neuromics |
1,000,000 cells |
Ask for price |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
20-abx155968 |
Abbexa |
-
EUR 8684.40
-
EUR 4626.00
-
EUR 1074.00
|
- 10 × 96 tests
- 5 × 96 tests
- 96 tests
|
|
Rat Ferritin (Liver) Antibody (Biotin Conjugate) |
11901-05021 |
AssayPro |
150 ug |
EUR 331.2 |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
abx573958-96tests |
Abbexa |
96 tests |
EUR 886.8 |
|
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
DLR-PFKL-Ra-48T |
DL Develop |
48T |
EUR 658.8 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Rat Phosphofructokinase, Liver (PFKL) in samples from tissue homogenates, cell lysates or other biological fluids. |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
DLR-PFKL-Ra-96T |
DL Develop |
96T |
EUR 861.6 |
|
Description: A sandwich quantitative ELISA assay kit for detection of Rat Phosphofructokinase, Liver (PFKL) in samples from tissue homogenates, cell lysates or other biological fluids. |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
RD-PFKL-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 668.4 |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
RD-PFKL-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 930 |
Rat Phosphofructokinase, Liver ELISA Kit (PFKL) |
RK03883 |
Abclonal |
96 Tests |
EUR 625.2 |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
RDR-PFKL-Ra-48Tests |
Reddot Biotech |
48 Tests |
EUR 699.6 |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
RDR-PFKL-Ra-96Tests |
Reddot Biotech |
96 Tests |
EUR 973.2 |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
SED406Ra-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 6149.04 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Phosphofructokinase, Liver (PFKL) in tissue homogenates, cell lysates and other biological fluids. |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
SED406Ra-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 611.57 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Phosphofructokinase, Liver (PFKL) in tissue homogenates, cell lysates and other biological fluids. |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
SED406Ra-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 822.24 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Phosphofructokinase, Liver (PFKL) in tissue homogenates, cell lysates and other biological fluids. |
Rat Phosphofructokinase, Liver (PFKL) ELISA Kit |
SED406Ra-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3340.08 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Phosphofructokinase, Liver (PFKL) in tissue homogenates, cell lysates and other biological fluids. |
N-Glucuronide and sequential TZD ring-opened metabolites have been additionally present in liver microsomes within the presence of UDP-glucuronic acid. The O-demethyl-O-sulfate (M11), which is the main in vivo metabolite in rats and monkeys, was detected in all species of hepatocytes. As well as, a TZD ring-opened S-cysteine conjugate (M15) was detected in human hepatocytes. From these outcomes, the in vivo metabolic pathways in people have been predicted to be the 4 oxidation and one N-glucuronidation pathways. The 4 oxidative metabolites have been fashioned by a number of human P450 enzymes, and N-glucuronide was fashioned by UGT1A3 and UGT2B7.