Asociación Española de Toxicología (AETOX) ISSN: 1697-0748

S9 fraction rat hepatocyte microsomes, slices, p450, beagle

MUSASHI-2 confers resistance to third-generation EGFR-tyrosine kinase inhibitor osimertinib in lung adenocarcinoma

Epidermal development issue receptor tyrosine kinase inhibitors (EGFR-TKIs) are efficient in sufferers with non-small cell lung most cancers (NSCLC) harboring EGFR mutations. Nevertheless, as a result of acquired resistance to EGFR-TKIs, even sufferers on third-generation osimertinib, have a poor prognosis. Resistance mechanisms are nonetheless not totally understood. Right here, we show that the elevated expression of MUSASHI-2 (MSI2), an...