Asociación Española de Toxicología (AETOX) ISSN: 1697-0748

S9 fraction rat hepatocyte microsomes, slices, p450, beagle

Protease-activated receptor-2 promotes osteogenesis in skeletal mesenchymal stem cells at the expense of adipogenesis: Involvement of interleukin-6

Bone marrow mesenchymal stem cells (MSCs) give rise to osteoblasts and adipocytes, with an inverse relationship between the 2. The MSCs from protease-activated receptor-2 knockout (PAR2 KO) mice have a decreased capability to generate osteoblasts. Right here we describe the commentary that PAR2 KO osteoblastic cultures generate extra adipocytes than wildtype (WT) cultures. Osteoblasts from PAR2 KO mice expressed decrease ranges of...