Asociación Española de Toxicología (AETOX) ISSN: 1697-0748

S9 fraction rat hepatocyte microsomes, slices, p450, beagle

Elevated progranulin contributes to synaptic and learning deficit due to loss of fragile X mental retardation protein.

Fragile X syndrome is an inheritable type of mental incapacity brought on by lack of fragile X psychological retardation protein (FMRP, encoded by the FMR1 gene). Absence of FMRP induced overexpression of progranulin (PGRN, encoded by GRN), a putative tumour necrosis issue receptor ligand. Within the current examine, we discovered that progranulin mRNA and protein had been upregulated within the medial prefrontal cortex of Fmr1 knock-out...