Klotho induces insulin resistance possibly through interference with GLUT4 translocation and activation of Akt, GSK3β, and PFKfβ3 in 3T3-L1 adipocyte cells.Klotho induces insulin resistance possibly through interference with GLUT4 translocation and activation of Akt, GSK3β, and PFKfβ3 in 3T3-L1 adipocyte cells.
Klotho is taken into account as an anti-aging issue inducing insulin resistance and concerned in kind 2 diabetes. Nevertheless, mechanisms by which klotho induces insulin resistance stay to be understood.