Blocking – Page 6 – Asociación Española de Toxicología (AETOX) ISSN: 1697-0748

Pharmacokinetic interaction studies of tanshinones with tolbutamide, a model CYP2C11 probe substrate, using liver microsomes, primary hepatocytes and in vivo in the rat.Pharmacokinetic interaction studies of tanshinones with tolbutamide, a model CYP2C11 probe substrate, using liver microsomes, primary hepatocytes and in vivo in the rat.

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The results of Danshen and its lively parts (tanshinone I, tanshinone IIA, dihydrotanshinone and cryptotanshinone) on tolbutamide 4-hydroxylation was investigated within the rat. Danshen (0.125-2mg/ml) decreased 4-hydroxy-tolbutamide formation in vitro

In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.

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The in vitro metabolism of rivaroxaban, a novel, oral, direct issue Xa inhibitor for the prevention and remedy of thromboembolic issues, was investigated in a number of species, together with

Biosynthesis of cytochrome P-450 on membrane-bound ribosomes and its subsequent incorporation into rough and smooth microsomes in rat hepatocytes.Biosynthesis of cytochrome P-450 on membrane-bound ribosomes and its subsequent incorporation into rough and smooth microsomes in rat hepatocytes.

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Intracellular websites of synthesis of cytochrome P-450 and the next incorporation of it into membrane buildings of the endoplasmic reticulum (ER) in rat hepatocytes have been studied utilizing an antibody